Tau conotoxin CnVA 

Tau conotoxin CnVA is a small peptide found in the venom of the Conus consors pit viper, belonging to the T1 pit viper peptide superfamily. Tau conotoxin CnVA shows a highly selective interaction with the somatostatin sst3 receptor (K_i=1.5 µM) and is the only toxin known to interact with this subfamily of G protein-coupled receptors (GPCRs). Tau conotoxin CnVA can be used in the study of diseases associated with the sst3 receptor, such as pancreatic cancer or pituitary adenomas^[1].

1718.10

C₇₂H₁₁₆N₂₄O₁₇S₄

1436463-45-4

Glu-Cys-Cys-His-Arg-Gln-Leu-Leu-Cys-Cys-Leu-Arg-Phe-Val-NH2 (Disulfide bridge: Cys2-Cys9; Cys3-Cys10)

ECCHRQLLCCLRFV-NH2 (Disulfide bridge: Cys2-Cys9; Cys3-Cys10)

O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CC(C)C)=O)CC(C)C)=O)CCC(N)=O)=O)CCCNC(N)=N)[C@@H](NC([C@@](CSSC[C@H](N2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N)=O)C(C)C)=O)CC3=CC=CC=C3)=O)=O)=O)([H])NC([C@H](CSSC[C@@](NC1=O)([H])C2=O)NC([C@@H](N)CCC(O)=O)=O)=O)=O)CC4=CN=CN4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Petrel C, et al. Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor[J]. Biochemical pharmacology, 2013, 85(11): 1663-1671.  [Content Brief]