Efmitermant alfa  (Synonyms: ACE083)

Efmitermant alfa (ACE-083) is a locally acting, follistatin-based fusion protein. Efmitermant alfa also is a muscle-promoting agent. Efmitermant alfa can be used for the research of muscle disorders^[1][2].

Human

ACE-083 (0-60 nM) has high affinity for heparin and extracellular matrix^[1].
ACE-083 (0- 20 μg/mL) binds and potently neutralizes myostatin, activin A, activin B and growth differentiation factor 11 (GDF11) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ACE-083 (i.m.; 0-100 μg; twice weekly for 4 weeks) causes localized, dose-dependent hypertrophy of the injected muscle in wild-type mice and mouse models of Charcot-Marie-Tooth disease (CMT) and Duchenne muscular dystrophy^[1].
ACE-083 (i.m.; 0-100 μg; twice weekly for 4 weeks) also increases the force of isometric contraction in situ by the injected tibialis anterior muscle in wild-type mice and disease models and increased ankle dorsiflexion torque in CMT mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1644543-31-6

[Efmitermant alfa]

Please store the product under the recommended conditions in the Certificate of Analysis.

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  [FST (follistatin)]2-IGHG2 Fc (Fragment constant)

• [1]. R S Pearsall, et al. Follistatin-based ligand trap ACE-083 induces localized hypertrophy of skeletal muscle with functional improvement in models of neuromuscular disease. Sci Rep. 2019 Aug 6;9(1):11392.  [Content Brief]

  [2]. Jeffrey M Statland, et al. Randomized phase 2 study of ACE-083, a muscle-promoting agent, in facioscapulohumeral muscular dystrophy. Muscle Nerve  [Content Brief]