MASTL

Microtubule‐associated serine/threonine kinase like

Microtubule‐associated serine/threonine kinase like (MASTL), also known as Greatwall (Gwl), is an important mitotic kinase that regulates mitotic progression of normal or transformed cells. The best-characterized substrates of MASTL kinase are cAMP-regulated phosphoprotein 19 (Arpp19) and endosulfine alpha (ENSA, identified due to its high homology with Arpp19), both of which contain the conserved MASTL phosphorylation motif FDSGDY. This kinase function of MASTL has primarily been associated with cell-cycle progression, where it facilitates effective mitotic exit through downregulation of the B55 subunit of protein phosphatase 2A (PP2A). This prevents excessive dephosphorylation by PP2A and mitotic collapse upon nuclear envelope breakdown.

MASTL Inhibitors (5)

MASTL Related Products (5):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-137552

MKI-1	Inhibitor	98.13%
MKI-1, an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC₅₀ of 9.9 μM, exerts antitumor and radiosensitizer activities through PP2A activation in breast cancer.

HY-162731

MASTL-IN-3	Inhibitor
MASTL-IN-3 (compound 60) is a potent MASTL inhibitor with a pIC₅₀ value of 9.10 M. MASTL-IN-3 shows anti-proliferative activity.

HY-156716

MASTL-IN-2	Inhibitor
MASTL-IN-2 is an MASTL (microtubule-associated serine/threonine kinase-like) inhibitor. MASTL-IN-2 inhibits human epithelial MIA PaCa cancer cell proliferation with IC₅₀ of 2.8 nM.

HY-156715

MASTL-IN-1	Inhibitor
MASTL-IN-1 is a MASTL (microtubule-associated serine/threonine kinase-like) inhibitor, which is involved in cell proliferation, migration, and invasion. MASTL-IN-1 has potential in cancer research.

HY-162732

MASTL-IN-4	Inhibitor
MASTL-IN-4(compound 70) is a potent MASTL inhibitor with a pIC₅₀ value of 9.15. MASTL-IN-4 shows anti-proliferative activity.

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