2. Gene
  3. Grm8 - glutamate receptor, metabotropic 8 Gene

Grm8 - glutamate receptor, metabotropic 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as GluR8; Gprc1h; mGluR8; A230002O04

Gene ID: 14823 | Gene type: protein coding

About Grm8

Chromosome 6: 27,275,118-28,135,177 reverse strand.GRCm39:CM000999.3

This gene has 7 transcripts (splice variants), 288 orthologues, 7 paralogues and is associated with 11 phenotypes. Biased expression in frontal lobe adult (RPKM 2.3), CNS E18 (RPKM 1.6) and 6 other tissues.

Summary

Enables group III metabotropic glutamate receptor activity. Predicted to be involved in several processes, including adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Predicted to act upstream of or within signal transduction. Predicted to be located in neuron projection; neuronal cell body; and presynaptic membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including eye; gonad; ileum; liver and biliary system; and nervous system. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8). [provided by Alliance of Genome Resources, Apr 2022]

Grm8 Products(16)

mRNA Protein Name
NM_001409909.1 NP_001396838.1 metabotropic glutamate receptor 8 isoform 5 precursor
NM_001409900.1 NP_001396829.1 metabotropic glutamate receptor 8 isoform 1 precursor
NM_001409912.1 NP_001396841.1 metabotropic glutamate receptor 8 isoform 8
NM_001409901.1 NP_001396830.1 metabotropic glutamate receptor 8 isoform 2 precursor
NM_001409903.1 NP_001396832.1 metabotropic glutamate receptor 8 isoform 2 precursor
NM_001311072.2 NP_001298001.1 metabotropic glutamate receptor 8 isoform 2 precursor
NM_001409908.1 NP_001396837.1 metabotropic glutamate receptor 8 isoform 5 precursor
NM_001409911.1 NP_001396840.1 metabotropic glutamate receptor 8 isoform 7
NM_001409910.1 NP_001396839.1 metabotropic glutamate receptor 8 isoform 6
NM_001409907.1 NP_001396836.1 metabotropic glutamate receptor 8 isoform 5 precursor
NM_008174.4 NP_032200.2 metabotropic glutamate receptor 8 isoform 1 precursor
NM_001409904.1 NP_001396833.1 metabotropic glutamate receptor 8 isoform 2 precursor
NM_001409905.1 NP_001396834.1 metabotropic glutamate receptor 8 isoform 3
NM_001409906.1 NP_001396835.1 metabotropic glutamate receptor 8 isoform 4
NM_001361125.2 NP_001348054.1 metabotropic glutamate receptor 8 isoform 1 precursor
NM_001409913.1 NP_001396842.1 metabotropic glutamate receptor 8 isoform 9

Grm8 Protein Structure

PBP1_mGluR_groupIII

PBP1_mGluR_groupIII: cd06376 (39 - 503)

NCD3G

NCD3G: pfam07562 (511 - 561)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (581 - 606)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (581 - 891)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (618 - 639)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (648 - 672)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (694 - 714)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (744 - 770)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (778 - 801)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (811 - 836)

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  • 908 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 8

G protein coupled receptor, family C, group 1, member H

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05840 GRM8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05841 Grm8 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS05842 Grm8 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grm8 NCBI NCBI:2918