N188 TFA 

N188 TFA is a radioligand based on a bicyclic peptide backbone that targets nectin-4, a protein overexpressed in many tumors. N188 TFA can be efficiently radiolabeled to 68Ga-N188, a radioisotope suitable for positron emission tomography (PET) imaging. The development of N188 TFA and its radiolabeled form 68Ga-N188 can be used for the diagnosis and treatment of tumors such as urothelial carcinoma^[1].

2545.85 (free acid)

C₁₁₃H₁₅₃N₂₇O₃₃S₄.xC₂HF₃O₂

Solid

White to off-white

O=C(N[C@@H](CSCCC(N1CN(C(CCSC[C@@H](C(N(CCC2)[C@]2([H])C(N[C@H]3CC4=CC(C=CC=C5)=C5C=C4)=O)=O)NC(CN(CCN(CC6)CC(O)=O)CCN(CCN6CC(O)=O)CC(O)=O)=O)=O)CN(C(CCSC[C@](C(N[C@H](C7=O)CCSC)=O)([H])NC([C@H](NC3=O)CC(O)=O)=O)=O)C1)=O)C(O)=O)[C@@H](NC([C@@](C[C@H]8O)([H])N(C8)C([C@@](CCC9)([H])N9C([C@](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N7)CCCNC(N)=N)=O)CC(O)=O)=O)CC%10=CNC%11=CC=CC=C%10%11)=O)CO)=O)([H])[C@H](O)C)=O)=O)=O)CC%12=CNC%13=CC=CC=C%12%13.OC(C(F)(F)F)=O.[x]

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Duan X, et al. First-in-Human Study of the Radioligand 68Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma. Clin Cancer Res. 2023 Sep 1;29(17):3395-3407.  [Content Brief]