1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. GlyT
  3. (Rac)-ALX 5407

NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion.

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(Rac)-ALX 5407 Chemical Structure

(Rac)-ALX 5407 Chemical Structure

CAS No. : 405225-21-0

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Description

NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively[1]. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion[2].

IC50 & Target[1]

hGlyT1

2.8 nM (IC50)

rGlyT1

9.8 nM (IC50)

Molecular Weight

393.45

Formula

C24H24FNO3

CAS No.
SMILES

OC(CN(C)CCC(C1=CC=C(F)C=C1)OC2=CC=C(C3=CC=CC=C3)C=C2)=O

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(Rac)-ALX 5407
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