2. Autophagy Neuronal Signaling
  3. PINK1/Parkin
  4. Penisterpenoid A

Penisterpenoid A (Compound 1) is a PINK1/Parkin mitochondrial autophagy signaling pathway activator, which can be isolated from the rhizosphere fungus Penicillium of the medicinal plant Bupleurum. Penicillioid A can reduce lipid accumulation and significantly improve mitochondrial function both in vitro and in vivo.

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Penisterpenoid A Chemical Structure

Penisterpenoid A Chemical Structure

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Penisterpenoid A Related Antibodies

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Description

Penisterpenoid A (Compound 1) is a PINK1/Parkin mitochondrial autophagy signaling pathway activator, which can be isolated from the rhizosphere fungus Penicillium of the medicinal plant Bupleurum. Penicillioid A can reduce lipid accumulation and significantly improve mitochondrial function both in vitro and in vivo[1].
In Vitro

Penisterpenoid A (Compound 1) (20 μM, 24 h) reduces lipid accumulation and exhibits lipid-lowering activity in human normal liver cell line LO2 by selectively activating the PINK1/Parkin mitochondrial autophagy signaling pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Penisterpenoid A Related Antibodies

Western Blot Analysis[1].

Cell Line: Human normal liver cell line LO2
Concentration: 20 μM
Incubation Time: 24 h
Result: Increased the protein expression of mitochondrial homeostasis and autophagy related proteins PINK1 and Parkin by 22.5% and 26.6%, respectively.
In Vivo

Penisterpenoid A (Compound 1) (20 μM; 72 h) can reduce lipid accumulation and improve mitochondrial function in a zebrafish model of non-alcoholic fatty liver disease[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Non-alcoholic fatty liver disease (NAFLD) zebrafish model[1].
Dosage: 20 μM
Administration: 72 h (NAFLD zabrafish were induced by 0.4 mg/mL Thioacetamide (HY-Y0698) for 72 h at 3 days post fertilization)
Result: Showed significant alleviation in ballooning generation and lipid accumulation in TAA-induced zebrafish model.
Molecular Weight

284.35

Formula

C15H24O5
SMILES

O=C(O)C1=CC[C@@]2(C)[C@@](CC1)([H])[C@@](O)(C(C)(O)C)[C@H](O)C2
Structure Classification
Initial Source

Penicillium sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Penisterpenoid A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Penisterpenoid APINK1/Parkinmitochondrionlipid-loweringautophagy pathwayInhibitorinhibitorinhibit

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