2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. PROTAC SMARCA2 degrader-4

PROTAC SMARCA2 degrader-4 (Compound I-424) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2 degrader-9 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 >1 μM. (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159532); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

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PROTAC SMARCA2 degrader-4 Chemical Structure

PROTAC SMARCA2 degrader-4 Chemical Structure

CAS No. : 2568523-70-4

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PROTAC SMARCA2 degrader-4 Related Antibodies

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Description

PROTAC SMARCA2 degrader-4 (Compound I-424) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2 degrader-9 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 >1 μM[1]. (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159532); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

Molecular Weight

1009.27

Formula

C55H68N12O5S
CAS No.
SMILES

O=C([C@H]1N(C[C@H](O)C1)C([C@@H](NC(C2CC3(CC(N4CCC(CC4)C5=CN=C(N6C7CN(CC6CC7)C8=C(N)N=NC(C9=CC=CC=C9O)=C8)N=C5)C3)C2)=O)C(C)(C)C)=O)NCC%10=CC=C(C%11=C(C)N=CS%11)C=C%10
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC SMARCA2 degrader-4 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SMARCA2 degrader-42568523-70-4PROTACsEpigenetic Reader DomainA549MV411Inhibitorinhibitorinhibit

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