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ITGA2B

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Compare Product Name Species Source
  • HY-P700754
    Integrin alpha 2B beta 3 Protein, Mouse (HEK293, His)

    α2Bβ3; ITGA2B&ITGB3; ITGA2B; ITGB3

    		 Mouse HEK293
    Integrin alpha-IIb/beta-3, a versatile receptor recognizing various ligands, plays a pivotal role in platelet function and hemostasis. It binds fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin, and vitronectin through the R-G-D sequence, particularly recognizing the H-H-L-G-G-G-A-K-Q-A-G-D-V sequence in fibrinogen. Activated, it facilitates platelet-platelet interactions by binding soluble fibrinogen, leading to rapid platelet aggregation. Structurally, it forms a heterodimer with the alpha subunit consisting of a heavy and a light chain linked by a disulfide bond, and the alpha-IIb subunit associates with beta-3. Its diverse interactions, including RNF181, CIB1-4, and PPIA/CYPA, underscore its integral role in orchestrating platelet responses. Integrin alpha 2B beta 3 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha 2B beta 3 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha 2B beta 3 Protein, Mouse (HEK293, His), has molecular weight of 90-113 kDa.

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