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DUSP6-IN-1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-168012
    DUSP6-IN-1

    		Ras Phosphatase Cancer
    DUSP6-IN-1 (compound 24) is an inhibitor targeting DUSP6, with IC50 values of 1.3 nM, 4.7 nM and 0.3 nM for KRAS G12C, G12D and G12V, respectively; IC50 values of 7 nM, 32 nM, 38 nM and 35 nM for the interaction of KRAS G12V, WT KRAS, WT HRAS and WT NRAS-BRAF with CYPA, respectively; IC50 values of 9.7 nM, 49.5 nM and 7.1 nM for KRAS-BRAF and CYPA under G12C, G12D and G12V, respectively; when inhibiting pERK, IC50 values for G12C and G12V are less than 0.6 nM, andIC50value for G12D is 0.9 nM .
    DUSP6-IN-1

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