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IsoA

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N13276
    Isoforretin A

    IsoA

    		 TrxR Reactive Oxygen Species Apoptosis Cancer
    Isoforretin A is a bioactive and potent inhibitor against Thioredoxin-1 (Trx1) which triggers ROS-mediated antitumor effects. Isoforretin A suppresses Trx1 activity through covalently binding to the Cys32/Cys35 residues of the activation sites of Trx1 and triggers ROS accumulation, resulting in DNA damage and Apoptosis in cancer cells. Isoforretin A also inhibits the growth of HepG2 tumors in a murine xenograft model of hepatocellular carcinoma .
    Isoforretin A

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