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Pathways Recommended: PROTAC
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PROTAC MLKL Degrader-2

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-169072
    PROTAC MLKL Degrader-2

    		PROTACs Mixed Lineage Kinase Cancer
    PROTAC MLKL Degrader-2 is a PROTAC targeting MLKL (Mixed Lineage Kinase). PROTAC MLKL Degrader-2 consists of PROTAC target protein ligand PROTAC MLKL Degrader-2 (HY-169072), E3 ligase ligand Thalidomide (HY-14658) and PROTAC Linker N-Methylpiperazine (HY-78871), of which the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-N-methylpiperazine (HY-169074). PROTAC MLKL Degrader-2 exhibits antinecroptotic activity on human cell lines and effectively degrades MLKL in the HT-29 xenograft mouse model .
    PROTAC MLKL Degrader-2
  • HY-169074
    Thalidomide-N-methylpiperazine

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide-N-methylpiperazine is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-N-methylpiperazine can be used to synthesize PROTAC MLKL Degrader-2 (HY-169072) to exhibit antinecroptotic activity on human cell lines and effectively degrade MLKL in the HT-29 xenograft mouse model .
    Thalidomide-N-methylpiperazine

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