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SMARCB1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Epigenetic Reader Domain (1) Histone Methyltransferase (3) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (4)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

CFT8634	Epigenetic Reader Domain	Cancer
CFT8634 is an oral activity degrader targeting BRD9 extracted from patent WO2021178920A1 compound 174. CFT8634 can be used for the research of synovial sarcoma and SMARCB1-deleted solid tumors ^[1] .

DM-01	Histone Methyltransferase	Cancer
DM-01 is a powerful and selective EZH2 inhibitor for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and SNF5/INI-1/SMARCB1 genetically defined solid tumors ^[1].

Tazemetostat 50+ Cited Publications EPZ-6438; E-7438	Histone Methyltransferase Apoptosis	Cancer
Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a K_i value of 2.5 nM. Tazemetostat inhibits EZH2 with IC₅₀s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC₅₀ of 4 nM. Tazemetostat also inhibits EZH1 with an IC₅₀ of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells ^[1].

SMARCB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMARCB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SMARCB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMARCB1 Human Pre-designed siRNA Set A SMARCB1 Human Pre-designed siRNA Set A

Tazemetostat (Standard)	Histone Methyltransferase Apoptosis	Cancer
Tazemetostat (Standard) is the analytical standard of Tazemetostat. This product is intended for research and analytical applications. Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a K_i value of 2.5 nM. Tazemetostat inhibits EZH2 with IC₅₀s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC₅₀ of 4 nM. Tazemetostat also inhibits EZH1 with an IC₅₀ of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells ^[1].

Cat. No.	Compare	Product Name	Application	Reactivity

	SMARCB1 Antibody (YA2018) SMARCB1; BAF47; hSNF5; INI1; RDT; RTPS1; Sfh1p; SMARCB1; SNF5 homolog; SNF5L1; Snr1; SWI/SNF comp	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse
	SMARCB1 Antibody (YA2018) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2018), targeting SMARCB1, with a predicted molecular weight of 44 kDa (observed band size: 44 kDa). SMARCB1 Antibody (YA2018) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse background.

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SMARCB1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SMARCB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SMARCB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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