2. Gene
  3. TSPAN32 - tetraspanin 32 Gene

TSPAN32 - tetraspanin 32 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ART1; PHMX; PHEMX; TSSC6

Gene ID: 10077 | Gene type: protein coding

About TSPAN32

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:2,302,013-2,318,204 (from NCBI)

This gene has 17 transcripts (splice variants), 102 orthologues and 32 paralogues. Biased expression in bone marrow (RPKM 10.4), spleen (RPKM 4.1) and 5 other tissues.

Summary

This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

TSPAN32 Products(1)

mRNA Protein Name
NM_139022.3 NP_620591.3 tetraspanin-32

TSPAN32 Protein Structure

Tetraspannin

Tetraspannin: Tetraspanin family (10 - 221)

  • 0
  • 100
  • 200
  • 300
  • 320 a.a.
Protein Preferred Names Protein Names

tetraspanin-32

pan-hematopoietic expression protein

Related Diseases

Diseases Alias
Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome

BWS

Exomphalos-Macroglossia-Gigantism Syndrome

Emg Syndrome

Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation

Emg Abnormality

Wbs

Exomphalos Macroglossia Gigantism Syndrome

Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation

Macroglossia Exomphalos Gigantism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15168 TSPAN32 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TSPAN32 MGD MGI:1350360
Rattus norvegicus TSPAN32 RGD RGD:1308721
Felis catus TSPAN32 VGNC VGNC:66632
Canis familiaris TSPAN32 VGNC VGNC:47921
Bos taurus TSPAN32 VGNC VGNC:54507
Macaca mulatta TSPAN32 VGNC VGNC:78920