2. Recombinant Proteins
  3. Cytokines and Growth Factors Immune Checkpoint Proteins CAR-T Related Proteins CD Antigens
  4. TNF Superfamily Stimulatory Immune Checkpoint Molecules NK Cell CD Proteins Macrophage CD Proteins
  5. TNF Superfamily Ligands
  6. CD27 Ligand/CD70

CD27 Ligand/CD70

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CD70 (CD27 Ligand) belongs to the tumor necrosis factor (TNF) family, is the ligand for CD27 (TNFRSF27)[1]. CD70 and CD27 are homotrimer type II and homodimer type I transmembrane glycoprotein, expressing on activated and resting T and B lymphocytes, respectively[2][3]. CD70 involves in tumor cells and regulatory T cells survival, enabling activation of innate and adaptive immunity. CD70 expresses in the mature dendritic cells and is up-regulated upon the triggering of CD40 or Toll-like receptors[4]. As for a wildly use of CD70 in animal disease model, the sequence of amino acids in human is very different from mouse (56.25%) and rat (55.79%). CD70 as one of the most frequently mutated genes in a series of diffuse large B cell lymphomas, especially acts in a crucial Epstein-Barr virus (EBV)-specific T cell immunity and more generally for the immune surveillance of B cells. CD70 inhibits EBV infection by restoring the expansion of EBV-specific T lymphocytes stimulated by the CD70-deficient EBV-infected B cells[2]. CD70 induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation[3]. CD70 is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis[5].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72740
    CD70 Protein, Human (HEK293, Fc)

    CD70 antigen; CD70; CD27 ligand; CD27LG; TNFSF7; CD27L

    		Human HEK293
    CD70 is the ligand of CD27 in activated T and B lymphocytes, is an important cytokine in CD70-CD27 pathway involving with the generation and maintenance of T cell immunity. CD70 is a surface antigen, also shows antiviral activity and regulates viability of tumor cells and regulatory T cells. As for CD70 protein in human contains transmembrane domain and transmembrane helix, belonging to the tumor necrosis factor (TNF) family. CD70 Protein, Human (HEK293, Fc) is 149 amino acids in length (Q45-P193) and is expressed in the HEK293 cells with C terminal hFc-tag.
  • HY-P700035AF
    Animal-Free CD70 Protein, Human (His)

    CD70 antigen; CD70; CD27 ligand; CD27LG; TNFSF7; CD27L

    		Human E. coli
    As a ligand of CD27, CD70 protein is an indispensable part of T cell immune coordination and is of particular importance in antiviral responses. The CD70-CD27 pathway emerged as a key player that contributes to the generation and maintenance of T cell-mediated immune responses. Animal-Free CD70 Protein, Human (His) is the recombinant human-derived animal-FreeCD70 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free CD70 Protein, Human (His) is 155 a.a., with molecular weight of ~18.08 kDa.
  • HY-P701287
    FITC-Labeled CD70 Trimer Protein, Human (HEK293, His-Flag)

    CD70; CD27LG; TNFSF7; TNFSF7G; CD27L

    		Human HEK293
    As a ligand of CD27, CD70 protein is an indispensable part of T cell immune coordination and is of particular importance in antiviral responses. The CD70-CD27 pathway emerged as a key player that contributes to the generation and maintenance of T cell-mediated immune responses. FITC-Labeled CD70 Trimer Protein, Human (HEK293, His-Flag) is the recombinant human-derived FITC-Labeled CD70 Trimer protein, expressed by HEK293 , with His labeled tag. The total length of FITC-Labeled CD70 Trimer Protein, Human (HEK293, His-Flag) is 142 a.a., with molecular weight (glycosylation form) of 50-55 kDa.
Cat. No. Product Name Effect Purity