2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Apolipoprotein

Apolipoprotein

Plasma lipoprotein metabolism is regulated and controlled by the specific apolipoprotein (apo-) constituents of the various lipoprotein classes. The major apolipoproteins include apoE, apoB, apoA-I, apoA-II, apoA-IV, apoC-I, apoC-II, and apoC-III. Specific apolipoproteins function in the regulation of lipoprotein metabolism through their involvement in the transport and redistribution of lipids among various cells and tissues, through their role as cofactors for enzymes of lipid metabolism, or through their maintenance of the structure of the lipoprotein particles.

Apolipoprotein Isoform Specific Products:

Apolipoprotein Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-145727
    Volanesorsen
    		Inhibitor
    Volanesorsen (ISIS 304801) is an antisense oligonucleotide inhibitor of apolipoprotein CIII (apo-CIII) mRNA that reduces triglyceride levels and improves insulin resistance. Volanesorsen is being studied in the treatment of hypertriglyceridemia, familial chylosiderosis syndrome, and type 2 diabetes.
    Volanesorsen
  • HY-145727A
    Volanesorsen sodium
    		Inhibitor
    Volanesorsen sodium is an antisense oligonucleotide thay targes Apolipoprotein C-III (APOC3) mRNA. Volanesorsen sodium is used for the study of familial chylomicronemia syndrome.
    Volanesorsen sodium
  • HY-RS00846
    APOC3 Human Pre-designed siRNA Set A
    		Inhibitor

    APOC3 Human Pre-designed siRNA Set A contains three designed siRNAs for APOC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    APOC3 Human Pre-designed siRNA Set A
    APOC3 Human Pre-designed siRNA Set A
  • HY-153491
    Olezarsen
    		Inhibitor
    Olezarsen is an N-acetyl-galactosamine-conjugated antisense oligonucleotide targeted to hepatic APOC3 mRNA to inhibit apolipoprotein C-III (apoC-III) production, in lowering triglyceride levels in patients at high risk for or with established cardiovascular disease.
    Olezarsen
  • HY-153491A
    Olezarsen sodium
    		Inhibitor
    Olezarsen sodium is an N-acetyl-galactosamine-conjugated antisense oligonucleotide targeted to hepatic APOC3 mRNA to inhibit apolipoprotein C-III (apoC-III) production, in lowering triglyceride levels in patients at high risk for or with established cardiovascular disease.
    Olezarsen sodium
Apolipoprotein Isoform Comparison

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