UBAC1 - UBA domain containing 1 Gene

Homo sapiens

Also known as KPC2; GBDR1; UBADC1

Gene ID: 10422 | Gene type: protein coding

About UBAC1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:135,932,969-135,961,373 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 32.5), testis (RPKM 24.1) and 25 other tissues.

Summary

Predicted to be involved in protein ubiquitination. Located in Golgi apparatus; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

UBAC1 Products(1)

mRNA	Protein	Name
NM_016172.3	NP_057256.2	ubiquitin-associated domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	16227581	GOA
enables proteasome binding	IDA IDA: Inferred from direct assay	16227581	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein maturation	IDA IDA: Inferred from direct assay	25860612	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16227581	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBAC1 Protein Structure

UBA

0
100
200
300
405 a.a.

Protein Preferred Names

Protein Names

ubiquitin-associated domain-containing protein 1

E3 ubiquitin-protein ligase subunit KPC2

Recombinant UBAC1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700392	UBAC1 Protein, Human (GST)	Q9BSL1 (M1-T405)	≥95%

Related Diseases

Diseases

Alias

Urinary Tract Infection

Urinary Tract Infections	Uti
Urinary Tract Infection Nos	Uti - [Urinary Tract Infection]
Uti Nos - [Urinary Tract Infection Nos]	Urosepsis Nos
E Coli Uti	E Coli Urinary Tract Infection
Escherichia Coli Uti

Pyelitis

Acute Pyelonephritis

Apn - [Acute Pyelonephritis]

Granulomatous Disease, Chronic, Autosomal Recessive, 3

CGD3	Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii
Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii	Granulomatous Disease, Chronic, Due To Ncf4 Deficiency
Chronic Granulomatous Disease 3, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 3
Autosomal Recessive Cytochrome B-Positive Cgd Type Iii	Cdg3
Chronic Granulomatous Disease Due To Ncf4 Deficiency	Cgd Autosomal Recessive Cytochrome B-Positive Type Iii
Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii	Granulomatous Disease Chronic Due To Ncf4 Deficiency
Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3

Blood Group, Globoside System

Globe Disease	GLOB
Blood Group System, Globoside

Parametritis

Pelvic Cellulitis

Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency

Congenital Myasthenic Syndrome 9	CMS9
Congenital Myasthenic Syndrome 9, Associated With Acetylcholine Receptor Deficiency	Myasthenic Syndrome, Congenital, Type 9, Associated With Acetylcholine Receptor Deficiency

Endophthalmitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15326	UBAC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UBAC1	MGD	MGI:1920995
Macaca mulatta	UBAC1	VGNC	VGNC:79837
Canis familiaris	UBAC1	VGNC	VGNC:48042
Felis catus	UBAC1	VGNC	VGNC:66752
Rattus norvegicus	UBAC1	RGD	RGD:1359542
Bos taurus	UBAC1	VGNC	VGNC:36567
Others	UBAC1	NCBI

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