2. Gene
  3. SMYD4 - SET and MYND domain containing 4 Gene

SMYD4 - SET and MYND domain containing 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ZMYND21

Gene ID: 114826 | Gene type: protein coding

About SMYD4

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,779,485-1,829,902 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 5 paralogues. Ubiquitous expression in ovary (RPKM 3.5), fat (RPKM 3.2) and 25 other tissues.

Summary

Predicted to enable metal ion binding activity and methyltransferase activity. Involved in heart development. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SMYD4 Products(1)

mRNA Protein Name
NM_052928.3 NP_443160.2 SET and MYND domain-containing protein 4
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
30110327 GOA
Biological Process GO Annotation Evidence Reference Source
involved in heart development IMP
IMP: Inferred from mutant phenotype
30110327 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMYD4 Protein Structure

TPR_11

TPR_11: TPR repeat (68 - 132)

SET

SET: SET domain (244 - 574)

zf-MYND

zf-MYND: MYND finger (296 - 335)

  • 0
  • 200
  • 400
  • 600
  • 804 a.a.
Protein Preferred Names Protein Names

SET and MYND domain-containing protein 4

Related Diseases

Diseases Alias
Shukla-Vernon Syndrome

SHUVER
Congenital Contractures Of The Limbs And Face, Hypotonia, And Developmental Delay

CLIFAHDD

Congenital Limbs-Face Contractures-Hypotonia-Developmental Delay Syndrome

Clifahdd Syndrome

Doid:0081048

Contractures, Limbs And Face, Congenital, Hypotonia, And Developmental Delay
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13468 SMYD4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SMYD4 VGNC VGNC:77752
Rattus norvegicus SMYD4 RGD RGD:1307369
Canis familiaris SMYD4 VGNC VGNC:46582
Mus musculus SMYD4 MGD MGI:2442796
Felis catus SMYD4 VGNC VGNC:65512
Bos taurus SMYD4 VGNC VGNC:35045