ELK4 - ETS transcription factor ELK4 Gene

Homo sapiens

Also known as SAP1

Gene ID: 2005 | Gene type: protein coding

About ELK4

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,607,943-205,632,011 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues, 28 paralogues and is associated with 48 phenotypes. Ubiquitous expression in prostate (RPKM 12.4), lymph node (RPKM 7.6) and 25 other tissues.

Summary

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

ELK4 Products(2)

mRNA	Protein	Name
NM_001973.4	NP_001964.2	ETS domain-containing protein Elk-4 isoform a
NM_021795.3	NP_068567.1	ETS domain-containing protein Elk-4 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	20145255	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11846562	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	22722849	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22722849	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22722849	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20145255	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELK4 Protein Structure

Ets

0
100
200
300
400
431 a.a.

Protein Preferred Names

Protein Names

ETS domain-containing protein Elk-4

ELK4, ETS transcription factor

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04307	ELK4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ELK4	VGNC	VGNC:40305
Mus musculus	ELK4	MGD	MGI:102853
Felis catus	ELK4	VGNC	VGNC:61812
Macaca mulatta	ELK4	VGNC	VGNC:72211
Rattus norvegicus	ELK4	RGD	RGD:1310504
Bos taurus	ELK4	VGNC	VGNC:28434

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