2. Gene
  3. ZP1 - zona pellucida glycoprotein 1 Gene

ZP1 - zona pellucida glycoprotein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OOMD; ZPB1; OOMD1; HEL163

Gene ID: 22917 | Gene type: protein coding

About ZP1

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,867,542-60,875,687 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 1.8), fat (RPKM 0.3) and 2 other tissues.

Summary

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. [provided by RefSeq, May 2014]

ZP1 Products(3)

mRNA Protein Name
NM_001391943.1 NP_001378872.1 zona pellucida sperm-binding protein 1 isoform 2
NM_001391944.1 NP_001378873.1 zona pellucida sperm-binding protein 1 isoform 3
NM_207341.4 NP_997224.2 zona pellucida sperm-binding protein 1 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
28886344 GOA
Cellular Component GO Annotation Evidence Reference Source
located in egg coat IDA
IDA: Inferred from direct assay
29895852 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZP1 Protein Structure

Zona_pellucida

Zona_pellucida: Zona pellucida-like domain (279 - 548)

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  • 638 a.a.
Protein Preferred Names Protein Names

zona pellucida sperm-binding protein 1

epididymis luminal protein 163

Related Diseases

Diseases Alias
Oocyte Maturation Defect 1

OOMD1

Oomd

Oocyte Maturation Defect, Type 1

Oocyte Maturation Defect
Female Infertility Due To Zona Pellucida Defect
Oocyte Maturation Defect 3

OOMD3

Oocyte Maturation Defect, Type 3
Infertility
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0961 Merbromin Inhibitor / Unkown
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-162158 DA ZP1 / Unkown
HY-RS16186 ZP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZP1 VGNC VGNC:78913
Felis catus ZP1 VGNC VGNC:67373
Mus musculus ZP1 MGD MGI:103073
Rattus norvegicus ZP1 RGD RGD:620604