2. Gene
  3. PADI1 - peptidyl arginine deiminase 1 Gene

PADI1 - peptidyl arginine deiminase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PDI; PAD1; PDI1; HPAD10

Gene ID: 29943 | Gene type: protein coding

About PADI1

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,205,128-17,246,007 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 235 orthologues and 4 paralogues. Biased expression in esophagus (RPKM 30.8) and skin (RPKM 4.2).

Summary

This gene encodes a member of the peptidyl arginine deiminase family of Enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I Enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This Enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

PADI1 Products(1)

mRNA Protein Name
NM_013358.3 NP_037490.2 protein-arginine deiminase type-1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
27393304 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables protein-arginine deiminase activity IDA
IDA: Inferred from direct assay
27393304 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12416996 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PADI1 Protein Structure

PAD_N

PAD_N: Protein-arginine deiminase (PAD) N-terminal domain (1 - 113)

PAD_M

PAD_M: Protein-arginine deiminase (PAD) middle domain (115 - 273)

PAD

PAD: Protein-arginine deiminase (PAD) (277 - 663)

  • 0
  • 200
  • 400
  • 600
  • 663 a.a.
Protein Preferred Names Protein Names

protein-arginine deiminase type-1

hPAD-colony 10

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09960 PADI1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PADI1 VGNC VGNC:106464
Canis familiaris PADI1 VGNC VGNC:44234
Mus musculus PADI1 MGD MGI:1338893
Rattus norvegicus PADI1 RGD RGD:3287
Felis catus PADI1 VGNC VGNC:64021
Bos taurus PADI1 VGNC VGNC:32545