ASB2 - ankyrin repeat and SOCS box containing 2 Gene

Homo sapiens

Also known as ASB-2

Gene ID: 51676 | Gene type: protein coding

About ASB2

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:93,934,166-93,976,570 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 211 orthologues and 2 paralogues. Biased expression in heart (RPKM 15.5), prostate (RPKM 8.6) and 12 other tissues.

Summary

This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin Ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

ASB2 Products(2)

mRNA	Protein	Name
NM_001202429.2	NP_001189358.1	ankyrin repeat and SOCS box protein 2 isoform 1
NM_016150.5	NP_057234.2	ankyrin repeat and SOCS box protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cullin family protein binding	IPI IPI: Inferred from physical interaction	21119685	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16325183	GOA
contributes to ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	16325183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	32179481	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	21119685	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16325183	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	24044920	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16325183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASB2 Protein Structure

Ank_4

Ank_2

Ank

Ank_2

SOCS_box

0
100
200
300
400
500
587 a.a.

Protein Preferred Names

Protein Names

ankyrin repeat and SOCS box protein 2

ankyrin repeat and SOCS box-containing protein 2a

Related Diseases

Diseases

Alias

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01067	ASB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ASB2	VGNC	VGNC:59960
Canis familiaris	ASB2	VGNC	VGNC:38163
Macaca mulatta	ASB2	VGNC	VGNC:69840
Bos taurus	ASB2	VGNC	VGNC:26196
Mus musculus	ASB2	MGD	MGI:1929743
Rattus norvegicus	ASB2	RGD	RGD:1306414

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