ING3 - inhibitor of growth family member 3 Gene

Homo sapiens

Also known as Eaf4; ING2; MEAF4; p47ING3

Gene ID: 54556 | Gene type: protein coding

About ING3

Cytogenetic location: 7q31.31 Genomic coordinates (GRCh38): 7:120,950,777-120,977,216 (from NCBI)

This gene has 6 transcripts (splice variants), 210 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 18.3), lymph node (RPKM 6.0) and 24 other tissues.

Summary

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce Apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and Bax. Overexpression of this gene has been shown to inhibit cell growth and induce Apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]

ING3 Products(2)

mRNA	Protein	Name
NM_019071.3	NP_061944.2	inhibitor of growth protein 3 isoform 1
NM_198267.2	NP_938008.1	inhibitor of growth protein 3 isoform 3

ING3 Protein Structure

ING

PHD

0
100
200
300
418 a.a.

Protein Preferred Names

Protein Names

inhibitor of growth protein 3

Related Diseases

Diseases

Alias

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lip
Squamous Cell Carcinoma, Head And Neck, Somatic	Carcinoma Of The Head And Neck
Squamous Cell Carcinomas Of Head And Neck	Scchn
Squamous Cell Carcinoma Of The Hypopharynx	Squamous Cell Carcinoma Of The Oropharynx
Squamous Cell Carcinoma Of Salivary Glands	Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses
Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses	Squamous Cell Carcinoma Of The Oral Cavity
Squamous Cell Carcinoma Of The Lip	Carcinoma, Squamous Cell Of Head And Neck
Lip Squamous Cell Carcinoma	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06809	ING3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ING3	VGNC	VGNC:30196
Macaca mulatta	ING3	VGNC	VGNC:73595
Rattus norvegicus	ING3	RGD	RGD:1310556
Felis catus	ING3	VGNC	VGNC:62922
Mus musculus	ING3	MGD	MGI:1919027
Canis familiaris	ING3	VGNC	VGNC:42018
Others	ING3	NCBI

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