PHF12 - PHD finger protein 12 Gene

Homo sapiens

Also known as PF1

Gene ID: 57649 | Gene type: protein coding

About PHF12

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,905,250-28,951,518 (from NCBI)

This gene has 17 transcripts (splice variants), 252 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 8.9), spleen (RPKM 8.2) and 25 other tissues.

Summary

Enables phosphatidylinositol binding activity and transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of Sin3 complex and transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2022]

PHF12 Products(3)

mRNA	Protein	Name
NM_001033561.2	NP_001028733.1	PHD finger protein 12 isoform 1
NM_001290131.2	NP_001277060.1	PHD finger protein 12 isoform 3
NM_020889.3	NP_065940.1	PHD finger protein 12 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	16893883	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11390640	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	22048773	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11390640	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22048773	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Sin3-type complex	IDA IDA: Inferred from direct assay	22048773	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11390640	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	11390640	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHF12 Protein Structure

PHD

0
200
400
600
800
1004 a.a.

Protein Preferred Names

Protein Names

PHD finger protein 12

PHD factor 1

Related Diseases

Diseases

Alias

Peroneal Nerve Paralysis

Peroneal Nerve Palsy

Heel Spur

Calcaneal Spur

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10416	PHF12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PHF12	VGNC	VGNC:44482
Macaca mulatta	PHF12	VGNC	VGNC:75838
Felis catus	PHF12	VGNC	VGNC:64138
Rattus norvegicus	PHF12	RGD	RGD:1305731
Mus musculus	PHF12	MGD	MGI:1924057
Bos taurus	PHF12	VGNC	VGNC:32814

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