SSR3 - signal sequence receptor subunit 3 Gene

Homo sapiens

Also known as TRAPG

Gene ID: 6747 | Gene type: protein coding

About SSR3

Cytogenetic location: 3q25.31 Genomic coordinates (GRCh38): 3:156,539,553-156,555,117 (from NCBI)

This gene has 9 transcripts (splice variants) and 223 orthologues. Ubiquitous expression in thyroid (RPKM 48.0), endometrium (RPKM 38.4) and 25 other tissues.

Summary

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]

SSR3 Products(4)

mRNA	Protein	Name
NM_001308197.2	NP_001295126.1	translocon-associated protein subunit gamma isoform 1
NM_001308204.2	NP_001295133.1	translocon-associated protein subunit gamma isoform 3
NM_001308205.2	NP_001295134.1	translocon-associated protein subunit gamma isoform 3
NM_007107.5	NP_009038.1	translocon-associated protein subunit gamma isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSR3 Protein Structure

TRAP-gamma

0
100
185 a.a.

Protein Preferred Names

Protein Names

translocon-associated protein subunit gamma

SSR gamma

Related Diseases

Diseases

Alias

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

Tylosis With Esophageal Cancer

Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome	TOC
Keratosis Palmaris Et Plantaris With Esophageal Cancer	Bennion-Patterson Syndrome
Howell-Evans Syndrome	Keratosis Palmoplantaris-Esophageal Carcinoma Syndrome
Palmoplantar Hyperkeratosis-Esophageal Carcinoma Syndrome	Tylosis-Oesophageal Carcinoma Syndrome
Palmoplantar Keratoderma With Esophageal Cancer	Howel-Evans Syndrome
Keratosis Palmoplantaris With Esophageal Cancer	Tylosis - Oesophageal Carcinoma
Howel-Evans' Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13816	SSR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SSR3	VGNC	VGNC:46839
Felis catus	SSR3	VGNC	VGNC:97645
Bos taurus	SSR3	VGNC	VGNC:35321
Mus musculus	SSR3	MGD	MGI:1914687
Rattus norvegicus	SSR3	RGD	RGD:621630
Macaca mulatta	SSR3	VGNC	VGNC:82769

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