2. Gene
  3. NEK4 - NIMA related kinase 4 Gene

NEK4 - NIMA related kinase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NRK2; STK2; pp12301

Gene ID: 6787 | Gene type: protein coding

About NEK4

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,708,444-52,770,940 (from NCBI)

This gene has 7 transcripts (splice variants), 204 orthologues and 35 paralogues. Broad expression in testis (RPKM 13.9), thyroid (RPKM 5.5) and 25 other tissues.

Summary

The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]

NEK4 Products(5)

mRNA Protein Name
NM_001193533.3 NP_001180462.1 serine/threonine-protein kinase Nek4 isoform 2
NM_001348412.2 NP_001335341.1 serine/threonine-protein kinase Nek4 isoform 3
NM_001348413.2 NP_001335342.1 serine/threonine-protein kinase Nek4 isoform 4
NM_001348414.2 NP_001335343.1 serine/threonine-protein kinase Nek4 isoform 5
NM_003157.6 NP_003148.2 serine/threonine-protein kinase Nek4 isoform 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
22851694 GOA
involved in mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
22851694 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
22851694 GOA
involved in regulation of cellular senescence IMP
IMP: Inferred from mutant phenotype
22851694 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEK4 Protein Structure

Pkinase

Pkinase: Protein kinase domain (7 - 261)

  • 0
  • 200
  • 400
  • 600
  • 841 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Nek4

NIMA (never in mitosis gene a)-related kinase 4

Related Diseases

Diseases Alias
Ciliopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09195 NEK4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NEK4 RGD RGD:1304995
Felis catus NEK4 VGNC VGNC:80635
Canis familiaris NEK4 VGNC VGNC:43732
Macaca mulatta NEK4 VGNC VGNC:81483
Bos taurus NEK4 VGNC VGNC:31995
Mus musculus NEK4 MGD MGI:1344404