2. Gene
  3. FZD3 - frizzled class receptor 3 Gene

FZD3 - frizzled class receptor 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Fz-3

Gene ID: 7976 | Gene type: protein coding

About FZD3

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:28,494,212-28,574,258 (from NCBI)

This gene has 4 transcripts (splice variants), 276 orthologues and 15 paralogues. Broad expression in brain (RPKM 6.0), ovary (RPKM 2.6) and 18 other tissues.

Summary

This gene is a member of the Frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most Frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]

FZD3 Products(18)

mRNA Protein Name
NM_001412905.1 NP_001399834.1 frizzled-3 isoform 2 precursor
NM_001412906.1 NP_001399835.1 frizzled-3 isoform 3
NM_001412907.1 NP_001399836.1 frizzled-3 isoform 4 precursor
NM_001412908.1 NP_001399837.1 frizzled-3 isoform 5
NM_001412909.1 NP_001399838.1 frizzled-3 isoform 6
NM_001412910.1 NP_001399839.1 frizzled-3 isoform 6
NM_001412911.1 NP_001399840.1 frizzled-3 isoform 1 precursor
NM_001412912.1 NP_001399841.1 frizzled-3 isoform 7
NM_001412913.1 NP_001399842.1 frizzled-3 isoform 7
NM_001412917.1 NP_001399846.1 frizzled-3 isoform 2 precursor
NM_001412919.1 NP_001399848.1 frizzled-3 isoform 6
NM_001412921.1 NP_001399850.1 frizzled-3 isoform 8 precursor
NM_001412922.1 NP_001399851.1 frizzled-3 isoform 9
NM_001412924.1 NP_001399853.1 frizzled-3 isoform 10
NM_001412925.1 NP_001399854.1 frizzled-3 isoform 10
NM_001412927.1 NP_001399856.1 frizzled-3 isoform 11
NM_017412.4 NP_059108.1 frizzled-3 precursor
NM_145866.2 NP_665873.1 frizzled-3 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
18256285 GOA
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
19038973 GOA
Biological Process GO Annotation Evidence Reference Source
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
20802536 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19038973 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19038973 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD3 Protein Structure

Fz

Fz: Fz domain (28 - 134)

Frizzled

Frizzled: Frizzled/Smoothened family membrane region (192 - 515)

  • 0
  • 200
  • 400
  • 600
  • 666 a.a.
Protein Preferred Names Protein Names

frizzled-3

frizzled 3, seven transmembrane spanning receptor

Related Diseases

Diseases Alias
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Multicystic Dysplastic Kidney

Multicystic Renal Dysplasia

Multicystic Kidney Dysplasia

Mcdk

Multiple Congenital Cysts Of Kidney

Developmental Multicystic Kidney
Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive

Hydrocephalus, X-Linked

Hydrocephalus Adverse Event

Hydrocephaly Nos
Fallopian Tube Serous Adenocarcinoma
Distal Arthrogryposis

Arthrogryposis Multiplex Congenita

Arthrogryposis

Congenital Multiple Arthrogryposis

Congenital Arthromyodysplasia

Fibrous Ankylosis Of Multiple Joints

Guerin-Stern Syndrome

Guérin-Stern Syndrome

Myodystrophia Fetalis Deformans

Otto Syndrome

Rocher-Sheldon Syndrome

Rossi Syndrome

Amc

Multiple Congenital Arthrogryposis

Arthrogryposis Syndrome

Arthrogryposis, Distal

Distal Arthrogryposis Syndrome

Freeman-Sheldon Syndrome

Arthrogryposis, Distal, Type 2b

Congenital Multiplex Arthrogryposis

Amyoplasia Congenita

Congenital Amyoplasia

Amc - [Arthrogryposis Multiplex Congenita]
Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Fallopian Tube Adenocarcinoma

Adenocarcinoma Of The Fallopian Tube
Schizophrenia 19

SCZD19

Schizophrenia 19 With Or Without An Affective Disorder

Schizophrenia 19, Susceptibility To

{Schizophrenia 19, Susceptibility To}
Substance-Induced Psychosis
Tethered Spinal Cord Syndrome

Spinal Dysraphism

Tethered Cord Syndrome

Occult Spinal Dysraphism

Occult Spinal Dysraphism Sequence

Segmental Vertebral Anomalies

Tethered Spinal Cord Disease

Tethered Cord

Spina Bifida Occulta

Cryptomerorachischisis

Spina Bifida Occulta With Tethered Spinal Cord

Sbo - [Spina Bifida Occulta]
Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Fetal Face Syndrome

Robinow Dwarfism

Mesomelic Dwarfism-Small Genitalia Syndrome

Robinow-Silverman-Smith Syndrome

Costovertebral Segmentation Defect With Mesomelia

Covesdem Syndrome

Robinow'S Syndrome

Robinow-Silverman Syndrome
Strabismus

Strabismus, Susceptibility To

Strabismus, Susceptibility To, 1

Strabismus 1
Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05179 FZD3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FZD3 VGNC VGNC:41031
Rattus norvegicus FZD3 RGD RGD:628814
Bos taurus FZD3 VGNC VGNC:58460
Mus musculus FZD3 MGD MGI:108476
Felis catus FZD3 VGNC VGNC:62405
Macaca mulatta FZD3 VGNC VGNC:72835
Others FZD3 NCBI