SETD3 - SET domain containing 3, actin histidine methyltransferase Gene

Homo sapiens

Also known as hSETD3; C14orf154

Gene ID: 84193 | Gene type: protein coding

About SETD3

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:99,397,748-99,486,458 (from NCBI)

This gene has 9 transcripts (splice variants), 216 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 33.6), kidney (RPKM 26.5) and 25 other tissues.

Summary

Enables protein-L-histidine N-tele-methyltransferase activity. Involved in actin modification and peptidyl-histidine methylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SETD3 Products(2)

mRNA	Protein	Name
NM_032233.3	NP_115609.2	actin-histidine N-methyltransferase isoform a
NM_199123.2	NP_954574.1	actin-histidine N-methyltransferase isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26030842	GOA
enables protein-L-histidine N-tele-methyltransferase activity	IDA IDA: Inferred from direct assay	30526847	GOA
NOT enables protein-lysine N-methyltransferase activity	IDA IDA: Inferred from direct assay	30785395	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin modification	IDA IDA: Inferred from direct assay	30526847	GOA
involved in peptidyl-histidine methylation	IDA IDA: Inferred from direct assay	30526847	GOA
NOT involved in peptidyl-lysine trimethylation	IDA IDA: Inferred from direct assay	30785395	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	30626964	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SETD3 Protein Structure

SET

Rubis-subs-bind

0
100
200
300
400
500
594 a.a.

Protein Preferred Names

Protein Names

actin-histidine N-methyltransferase

SET domain-containing protein 3

Related Diseases

Diseases

Alias

Acute Flaccid Myelitis

Sotos Syndrome 3

Sotos3

Sotos Syndrome, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12743	SETD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SETD3	RGD	RGD:1309550
Bos taurus	SETD3	VGNC	VGNC:34494
Canis familiaris	SETD3	VGNC	VGNC:46055
Mus musculus	SETD3	MGD	MGI:1289184
Felis catus	SETD3	VGNC	VGNC:65042
Macaca mulatta	SETD3	VGNC	VGNC:77285

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