2. Gene
  3. USP38 - ubiquitin specific peptidase 38 Gene

USP38 - ubiquitin specific peptidase 38 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HP43.8KD

Gene ID: 84640 | Gene type: protein coding

About USP38

Cytogenetic location: 4q31.21 Genomic coordinates (GRCh38): 4:143,184,917-143,223,874 (from NCBI)

This gene has 9 transcripts (splice variants), 205 orthologues and 71 paralogues. Ubiquitous expression in bone marrow (RPKM 7.3), colon (RPKM 5.9) and 25 other tissues.

Summary

Enables thiol-dependent Deubiquitinase. Involved in protein deubiquitination. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

USP38 Products(4)

mRNA Protein Name
NM_001290325.1 NP_001277254.1 ubiquitin carboxyl-terminal hydrolase 38 isoform 2
NM_001290326.1 NP_001277255.1 ubiquitin carboxyl-terminal hydrolase 38 isoform 3
NM_001410848.1 NP_001397777.1 ubiquitin carboxyl-terminal hydrolase 38 isoform 4
NM_032557.6 NP_115946.2 ubiquitin carboxyl-terminal hydrolase 38 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
14715245 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
enables protein sequestering activity IDA
IDA: Inferred from direct assay
34102342 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of innate immune response IDA
IDA: Inferred from direct assay
27692986 GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
34102342 GOA
involved in protein K33-linked deubiquitination IDA
IDA: Inferred from direct assay
27692986 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
27692986 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP38 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (445 - 946)

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  • 1042 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 38

deubiquitinating enzyme 38

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15549 USP38 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris USP38 VGNC VGNC:48193
Macaca mulatta USP38 VGNC VGNC:79224
Felis catus USP38 VGNC VGNC:66884
Bos taurus USP38 VGNC VGNC:36727
Mus musculus USP38 MGD MGI:1922091
Rattus norvegicus USP38 RGD RGD:1311974