2. Gene
  3. DCLK3 - doublecortin like kinase 3 Gene

DCLK3 - doublecortin like kinase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CLR; DCK3; DCDC3C; DCAMKL3

Gene ID: 85443 | Gene type: protein coding

About DCLK3

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:36,712,421-36,764,553 (from NCBI)

This gene has 3 transcripts (splice variants), 192 orthologues and 22 paralogues. Biased expression in testis (RPKM 2.2), brain (RPKM 0.5) and 6 other tissues.

Summary

Predicted to enable protein kinase activity. Predicted to be involved in peptidyl-serine phosphorylation. Predicted to act upstream of or within negative regulation of protein localization to nucleus. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

DCLK3 Products(2)

mRNA Protein Name
NM_001394672.2 NP_001381601.1 serine/threonine-protein kinase DCLK3 isoform 1
NM_033403.1 NP_208382.1 serine/threonine-protein kinase DCLK3 isoform 2

DCLK3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (356 - 613)

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  • 648 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase DCLK3

CLICK-I,II-related

Related Diseases

Diseases Alias
Multidrug-Resistant Tuberculosis

Tuberculosis, Multidrug-Resistant

Tuberculosis Multidrug-Resistant
Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia

XLN

SCNX

Severe Congenital Neutropenia X-Linked

Neutropenia, Congenital, Severe, X-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03580 DCLK3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DCLK3 VGNC VGNC:59331
Mus musculus DCLK3 MGD MGI:3039580
Felis catus DCLK3 VGNC VGNC:61369
Macaca mulatta DCLK3 VGNC VGNC:71671
Rattus norvegicus DCLK3 RGD RGD:1309232
Canis familiaris DCLK3 VGNC VGNC:39805