DHRS3 - dehydrogenase/reductase 3 Gene

Homo sapiens

Also known as SDR1; RDH17; Rsdr1; DD83.1; SDR16C1; retSDR1

Gene ID: 9249 | Gene type: protein coding

About DHRS3

Cytogenetic location: 1p36.21 Genomic coordinates (GRCh38): 1:12,567,910-12,618,210 (from NCBI)

This gene has 4 transcripts (splice variants), 225 orthologues, 25 paralogues and is associated with 1 phenotype. Ubiquitous expression in liver (RPKM 41.2), fat (RPKM 39.1) and 25 other tissues.

Summary

Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and Steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]

DHRS3 Products(3)

mRNA	Protein	Name
NM_001319225.2	NP_001306154.1	short-chain dehydrogenase/reductase 3 isoform 2
NM_001324370.2	NP_001311299.1	short-chain dehydrogenase/reductase 3 isoform 2
NM_004753.7	NP_004744.2	short-chain dehydrogenase/reductase 3 isoform 1

DHRS3 Protein Structure

adh_short

0
100
200
302 a.a.

Protein Preferred Names

Protein Names

short-chain dehydrogenase/reductase 3

dehydrogenase/reductase (SDR family) member 3

Related Diseases

Diseases

Alias

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Amphetamine Abuse

Microphthalmia, Syndromic 9

Matthew-Wood Syndrome	Spear Syndrome
Anophthalmia/Microphthalmia And Pulmonary Hypoplasia	Microphthalmia, Isolated, With Coloboma 8
MCOPS9	Anophthalmia, Clinical, With Mild Facial Dysmorphism And Variable Malformations Of The Lung, Heart, And Diaphragm
Pulmonary Hypoplasia-Diaphragmatic Hernia-Anophthalmia-Cardiac Defect	Pdac
Pulmonary Agenesis, Microphthalmia, And Diaphragmatic Defect	Pmd
Syndromic Microphthalmia 9	Anophthalmia-Pulmonary Hypoplasia Syndrome
Clinical Anophthalmia Mild Facial Dysmorphism Lung Heart And Diaphragm Malformations	Pulmonary Agenesis Microphthalmi And Diaphragmatic Defect
Microphthalmia Syndromic 9	Matthew Wood Syndrome
Pdac Syndrome	Pulmonary Hypoplasia-Diaphragmatic Hernia-Anophthalmia-Cardiac Defect Syndrome
Microphthalmia, Isolated, With Coloboma, 8	MCOPCB8
Isolated Colobomatous Microphthalmia 8	Microphthalmia, Syndromic, 9
Anophthalmia With Pulmonary Hypoplasia	Microphthalmia Syndromic, Type 9
Anophthalmia And Pulmonary Hypoplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03741	DHRS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DHRS3	VGNC	VGNC:71649
Rattus norvegicus	DHRS3	RGD	RGD:1305584
Felis catus	DHRS3	VGNC	VGNC:61470
Bos taurus	DHRS3	VGNC	VGNC:97260
Mus musculus	DHRS3	MGD	MGI:1315215
Canis familiaris	DHRS3	VGNC	VGNC:39934

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