KCNG4 - potassium voltage-gated channel modifier subfamily G member 4 Gene

Homo sapiens

Also known as KV6.3; KV6.4

Gene ID: 93107 | Gene type: protein coding

About KCNG4

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:84,218,657-84,240,012 (from NCBI)

This gene has 2 transcripts (splice variants), 294 orthologues and 31 paralogues. Low expression observed in reference dataset.

Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the Potassium Channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]

KCNG4 Products(1)

mRNA	Protein	Name
NM_172347.3	NP_758857.1	potassium voltage-gated channel subfamily G member 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	12060745	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	19074135	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	19074135	GOA
involved in regulation of potassium ion transport	IDA IDA: Inferred from direct assay	12060745	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12060745	GOA
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	19074135	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNG4 Protein Structure

BTB_2

Ion_trans

0
100
200
300
400
519 a.a.

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily G member 4

potassium channel, voltage gated modifier subfamily G, member 4

Related Diseases

Diseases

Alias

Night Blindness, Congenital Stationary, Type 1d

Congenital Stationary Night Blindness 1d	CSNB1D
Csnb, Complete, Autosomal Recessive	Night Blindness, Congenital Stationary , 1d, Autosomal Recessive
Congenital Stationary Night Blindness 1d Autosomal Recessive	Night Blindness, Congenital Stationary, 1d
Complete Autosomal Recessive Csnb	Blindness, Night, Stationary, Congenital, Type 1d

Retinal Cone Dystrophy 3b

RCD3B	Cone Dystrophy With Supernormal Rod Response
Cone Dystrophy With Supernormal Rod Electroretinogram	Cone Dystrophy With Supernormal Rod Responses
Cdsrr	Cone Dystrophy With Night Blindness And Supernormal Rod Responses, Kcnv2-Related
Cone Dystrophy With Night Blindness And Supernormal Rod Responses Kcnv2 Related	Cone Dystrophy With Supernormal Rod Erg
Cone Dystrophy With Supernormal Scotopic Electroretinogram	Cone Dystrophy Retinal 3b
Cone Dystrophy With Night Blindness And Supernormal Rod Responses Kcnv2-Related	Doid:0081022
Dystrophy, Retinal Cone, Type 3b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07124	KCNG4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KCNG4	VGNC	VGNC:42247
Bos taurus	KCNG4	VGNC	VGNC:30444
Macaca mulatta	KCNG4	VGNC	VGNC:82166
Mus musculus	KCNG4	MGD	MGI:1913983
Rattus norvegicus	KCNG4	RGD	RGD:1308553
Felis catus	KCNG4	VGNC	VGNC:63036

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