2. Academic Validation
  3. 5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)

5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)

  • Bioorg Med Chem Lett. 2003 May 5;13(9):1577-80. doi: 10.1016/s0960-894x(03)00134-3.
Jason Witherington 1,  Vincent Bordas,  Stephen L Garland,  Deirdre M B Hickey,  Robert J Ife,  John Liddle,  Martin Saunders,  David G Smith,  Robert W Ward
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline Research Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. jason_witherington@gsk.com
PMID: 12699759 DOI: 10.1016/s0960-894x(03)00134-3
Abstract

A novel series of pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3).

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