2. Academic Validation
  3. Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015

Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015

  • Org Lett. 2006 Dec 7;8(25):5709-12. doi: 10.1021/ol062257t.
Rui H Jiao 1,  Shu Xu,  Jun Y Liu,  Hui M Ge,  Hui Ding,  Chen Xu,  Hai L Zhu,  Ren X Tan
Affiliations

Affiliation

  • 1 Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
PMID: 17134253 DOI: 10.1021/ol062257t
Abstract

Chaetominine (1), an alkaloidal metabolite with a new framework, was characterized from the solid-substrate culture of Chaetomium sp. IFB-E015, an endophytic fungus on the apparently healthy Adenophora axilliflora leaves. Its structure was determined by a combination of its spectral data and single-crystal X-ray diffraction analysis, with its absolute configuration elucidated by Marfey's method. Chaetominine was more cytotoxic than 5-fluorouracil against the human leukemia K562 and colon Cancer SW1116 cell lines. [structure: see text]

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