2. Academic Validation
  3. Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF)

Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF)

  • J Nat Prod. 2013 May 24;76(5):817-23. doi: 10.1021/np3004497.
Wei-Lun Yu 1,  Brian D Jones,  Minjin Kang,  Justin C Hammons,  James J La Clair,  Michael D Burkart
Affiliations

Affiliation

  • 1 Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, United States.
PMID: 23659282 DOI: 10.1021/np3004497
Abstract

Spirohexenolides A and B comprise a unique family of spirotetronate Natural Products. We report on the identification of their binding to and modulation of human macrophage migration inhibitor factor (hMIF). Using an immunoaffinity-fluorescent labeling method, the properties of this interaction are detailed and evidence is provided that hMIF plays a key role in the cytostatic activity of the spirohexenolides.

Figures
Products