2. Academic Validation
  3. Factor Xa: Thrombokinase from Paul Morawitz to J Haskell Milstone

Factor Xa: Thrombokinase from Paul Morawitz to J Haskell Milstone

  • J Thromb Thrombolysis. 2021 Aug;52(2):364-370. doi: 10.1007/s11239-021-02387-6.
Leonard M Milstone 1
Affiliations

Affiliation

  • 1 Department of Dermatology, Yale Medical School, 333 Cedar St, New Haven, CT, 06520-8059, USA. leonard.milstone@yale.edu.
PMID: 33484373 DOI: 10.1007/s11239-021-02387-6
Abstract

In 1904 Paul Morawitz postulated that an Enzyme, which he named thrombokinase, would be the primary activator of prothrombin. Fifty years passed before J Haskell Milstone isolated, purified and functionally characterized the Enzyme we now call Factor Xa. This essay summarizes Milstone's work on thrombokinase, and finds context for why his efforts succeeded while Others struggled.

Keywords

Coagulation; Enzyme; Factor X; Protein purification; Thrombokinase; Zymogen.

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