2. Immunology/Inflammation
  3. Toll-like Receptor (TLR) Interleukin Related NOD-like Receptor (NLR)
  4. RC529-MDP

RC529-MDP is an immunoadjuvant, combination of Toll-like Receptor (TLR) (TLR4a) and NOD-like Receptor (NOD2a), which enhances innate immune responses. BRC529-MDP activity depends on the TLR4 and NOD2 signaling pathways. RC529-MDP induces high levels of cytokine Interleukin Related (IL-6) in a mouse model, has immune-stimulating activity. RC529-MDP increases OVA-specific antibody responses, T cell responses, and the proportion of memory T cells in an OVA (HY-P0286)-injected mouse model.

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RC529-MDP Chemical Structure

RC529-MDP Chemical Structure

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RC529-MDP Related Antibodies

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Description

RC529-MDP is an immunoadjuvant, combination of Toll-like Receptor (TLR) (TLR4a) and NOD-like Receptor (NOD2a), which enhances innate immune responses. BRC529-MDP activity depends on the TLR4 and NOD2 signaling pathways. RC529-MDP induces high levels of cytokine Interleukin Related (IL-6) in a mouse model, has immune-stimulating activity. RC529-MDP increases OVA-specific antibody responses, T cell responses, and the proportion of memory T cells in an OVA (HY-P0286)-injected mouse model[1].

IC50 & Target

IL-6

 

TLR4

 

NOD2

 

In Vitro

BRC529-MDP (9.3 μM, 20 h) activity depends on the TLR4 and NOD2 signaling pathways[1].
RC529-MDP (conjugate) increases the proportion of CD80 and CD86 cells in Raw264.7 cells by 1.7 times compared with RC529 + MDP (mixture), effectively promoting the maturation of antigen-presenting cell (APC)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RC529-MDP Related Antibodies
In Vivo

RC529-MDP increases IL-6 levels in mice by 6.8-fold, resulting in a strong synergistic effect [1].
RC529-MDP (22.53μg, i.p.) enhances humoral immunity in the mouse model and also enhanced the levels of IgG subtypes (IgG1, IgG2a and IgG2b) [1].
RC529-MDP (22.53 μg, s.c.) and OVA are injected into the mouse model simultaneously, adaptive humoral immunity is rapidly activated, the number of T cells secreting cytokines increase, and strong cellular immunity is generated[1].
RC529-MDP (22.53μg) increases the proportion of central memory T cells (Tcm) and produced a memory response[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The mice were injected subcutaneously (S.C.) with the RC529-MDP and model antigen ovalbumin (OVA)[1]
Dosage: 22.53 μg
Administration: Subcutaneous injection (s.c.) on days 1, 15, 29
Result: Induced high levels of OVA-specific IgG, and the levels of IgG subtypes were increased.
Induced a 1.3-fold and 3.3-fold increase in the proportion of TNF-α and IFN-γ double-positive secreting CD4+ T and CD8+ T cells compared with RC529 + MDP.
Induced the proportion of central memory T cells (Tcm) of CD8+ and CD4+ cells to increase by 2.7 and 1.2 times compared with RC529 + MDP.
Animal Model: BALB/c mouse[1]
Dosage: 22.53 μg
Administration: Intraperitoneal injection (i.p.)
Result: Bound to RC529-MDP-induced OVA-specific IgG 2.0 times higher than that induced by RC529 + MDP without binding.
Molecular Weight

2252.99

Formula

C118H215N10O28P
SMILES

O=C(NC[C@@H]1[C@@H](OP(O)(O)=O)[C@H](OC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)[C@@H](NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)[C@H](OCCNC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O1)CCC2=CN(N=N2)CCO[C@H]3[C@H](NC(C)=O)[C@@H](O[C@@H](C(N[C@@H](C)C(N[C@@H](C(N)=O)CCC(O)=O)=O)=O)C)[C@H](O)[C@@H](CO)O3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RC529-MDP Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RC529-MDPToll-like Receptor (TLR)Interleukin RelatedNOD-like Receptor (NLR)ILTLR4aNOD2aAPCsOVAThe memory T cellsT cellInhibitorinhibitorinhibit

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