ABCC4 Protein, Human (HEK293, GFP, Strep, His)

ABCC4 Protein, an ATP-binding cassette (ABC) family member, actively transports endogenous compounds (cAMP, cGMP, bile acids) and xenobiotics from cells. Its versatility extends to glutathione conjugates (LTC4, LTB4) and drug metabolites, mediating cotransport of bile acids with reduced glutathione. ABCC4's function includes resistance to anticancer agents like methotrexate, highlighting its role in cellular communication and drug transport. ABCC4 Protein, Human (HEK293, GFP, Strep, His) is the recombinant human-derived ABCC4 protein, expressed by HEK293 , with C-10*His, C-GFP, C-Strep labeled tag. The total length of ABCC4 Protein, Human (HEK293, GFP, Strep, His) is 1325 a.a., .

ABCC4 protein, a member of the ATP-binding cassette (ABC) family, operates as an ATP-dependent transporter responsible for actively extruding both physiological compounds and xenobiotics from cells. It exhibits versatility in transporting endogenous molecules crucial for cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. ABCC4 also plays a role in the ATP-dependent efflux of glutathione conjugates, such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4), with the presence of glutathione being essential for the transport of LTB4 but not LTC4. Furthermore, it mediates the cotransport of bile acids with reduced glutathione. The functional scope of ABCC4 extends to the transport of a diverse array of drugs and their metabolites, encompassing anticancer, antiviral, and antibiotic molecules, thereby conferring resistance to certain anticancer agents, including methotrexate.

Human

HEK293

C-10*His;C-GFP;C-Strep

O15439 (M1-L1325)

10257

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.