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  4. RU265 trichloride

Ru265 trichloride is a cell-permeable mitochondrial calcium uniporter (MCU) inhibitor and can be used for the research of ischemic stroke.

For research use only. We do not sell to patients.

RU265 trichloride Chemical Structure

RU265 trichloride Chemical Structure

CAS No. : 27056-01-5

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Based on 1 publication(s) in Google Scholar

RU265 trichloride Related Antibodies

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Description

Ru265 trichloride is a cell-permeable mitochondrial calcium uniporter (MCU) inhibitor and can be used for the research of ischemic stroke[1].

IC50 & Target

Mitochondrial calcium uniporter[1]
In Vitro

Ru265 (1-10 μM; 30 min or 24 h) produces a concentration-dependent protection of cortical neurons against oxygen–glucose deprivation (OGD)[1].
Ru265 (10 μM; 30 min) blocks calpain activation in cortical neurons subjected to OGD[1].
Ru265 (50 μM; 24 or 48 h) preserves mitochondrial respiration and glycolysis in OGD-treated cortical neurons[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RU265 trichloride Related Antibodies

Cell Viability Assay[1]

Cell Line: Mouse cortical neurons
Concentration: 1-10 μM
Incubation Time: 24 h before OGD (90 min)
Result: Produced a concentration-dependent elevation of cell viability 24 h later with an EC50 of 5.0 µM.
In Vivo

Ru265 (3-30 mg/kg; i.p.; once) produces dose-dependent increases in seizure-like behaviours in mice[1].
Ru265 (1-10 mg/kg; i.p.; once) reduces hypoxic/ischemic-induced sensorimotor deficits and brain injury in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57/Bl6 mice[1]
Dosage: 3, 10 and 30 mg/kg
Administration: Intraperitoneal injection, once
Result: Dose-dependently increased pro-convulsant effects.
Molecular Weight

529.66

Formula

Cl5H24N9Ru2
CAS No.
SMILES

[Cl-][Ru+4]([NH3])([NH3])([NH3])([NH3])[N-3][Ru+4]([NH3])([NH3])([NH3])([NH3])[Cl-].[Cl-].[Cl-].[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RU265 trichloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RU265 trichloride27056-01-5Otherscortical neuronoxygen–glucose deprivationOGDmitochondrial calcium uniporterMCUC57/Bl6Inhibitorinhibitorinhibit

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RU265 trichloride
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HY-47847
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