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548470-11-7

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By Targets:	Biochemical Assay Reagents (1) Eukaryotic Initiation Factor (eIF) (1)
By Research Areas:	Neurological Disease (1)

Targets Recommended: 11β-HSD SHP2

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12495A

ISRIB 10+ Cited Publications	Biochemical Assay Reagents Eukaryotic Initiation Factor (eIF)	Neurological Disease
ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research .

Cat. No.	Product Name	Type

HY-12495A

ISRIB 10+ Cited Publications	Cell Assay Reagents
ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research .

ISRIB

10+ Cited Publications

Cell Assay Reagents

ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research .

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MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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548470-11-7

Inhibitors & Agonists

Biochemical Assay Reagents