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Results for "

Ack1

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

1

Recombinant Proteins

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15811
    XMD8-87

    Ack1-B19

    		 Tyrosinase Cancer
    XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively.
    XMD8-87
  • HY-12331
    KRCA-0008
    1 Publications Verification

    		 Ack1 Anaplastic lymphoma kinase (ALK) Apoptosis Cancer
    KRCA-0008 is a selective ALK/Ack1 inhibitor with IC50s of 12 and 4 nM for ALK and Ack1, respectively. KRCA-0008 can be used for the research of cancer [1] .
    KRCA-0008
  • HY-15290
    AIM-100
    3 Publications Verification

    		 Ack1 Cancer
    AIM-100 is a potent and selective Ack1 inhibitor with an IC50 of 21.58 nM. AIM-100 also inhibits Tyr 267 phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect [1] .
    AIM-100
  • HY-10943
    GNF-7
    2 Publications Verification

    		 Bcr-Abl Ack1 Cancer
    GNF-7 is a multikinase inhibitor. GNF-7 is a Bcr-Abl inhibitor, with IC50s of 133 nM and 61 nM for Bcr-Abl WT and Bcr-Abl T315I, respectively. GNF-7 also possesses inhibitory activity against both ACK1 (activated CDC42 kinase 1) and GCK (germinal center kinase) with IC50s of 25 nM and 8 nM, respectively. GNF-7 can be used for the research of hematologic malignancies [1] .
    GNF-7
  • HY-160635
    Ack1 inhibitor 2

    		Ack1 Cancer
    Ack1 inhibitor 2 (Example 259) is an Ack1 inhibitor (IC50: 0.46 μM) [1].
    Ack1 inhibitor 2
  • HY-149989
    Ack1 inhibitor 1

    		Ack1 Akt Cancer
    Ack1 inhibitor 1 is a potent, selective, and orally active inhibitor of ACK1 kinase with an IC50 value of 2.1 nM. Ack1 inhibitor 1 inhibits the phosphorylation of ACK1 and activation of downstream AKT. Ack1 inhibitor 1 has anti-tumor activity [1].
    Ack1 inhibitor 1
  • HY-162254
    EGFR/ACK1-IN-1

    		EGFR Ack1 Cancer
    EGFR T790M/L858R/ACK1-IN-1 is a dual inhibitor of EGFR T790M/L858R and ACK1. IC50 values are 23 and 263 nM, respectively. EGFR T790M/L858R/ACK1-IN-1 can inhibit cell proliferation and has antitumor activity [1].
    EGFR/ACK1-IN-1

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