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Pathways Recommended: PI3K/Akt/mTOR
Results for "

Akt/mTOR-IN-1

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

1

Fluorescent Dye

3

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0901
    Corynoxine

    		Autophagy Neurological Disease Cancer
    Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .
    Corynoxine
  • HY-N3354
    Lupiwighteone

    8-prenylgenisteIN

    		 Apoptosis Cancer
    Lupiwighteone is an isoflavone present widely in wild-growing plants, with antioxidant, antimicrobial and anticancer effects. Lupiwighteone induces caspase-dependent and -independent apoptosis on human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway .
    Lupiwighteone
  • HY-161857
    Akt/mTOR-IN-1

    		Akt mTOR Caspase CDK Cancer
    Akt/mTOR-IN-1 (Compound 8r) is an AKT/mTOR signaling pathway inhibitor exhibiting an IC50 value of 0.8 µM with anticancer activity. Akt/mTOR-IN-1 can decrease the expression of Caspase 3 and increase the expression of the autophagic protein Cyclin B1, thereby inducing cell autophagy and apoptosis. Akt/mTOR-IN-1 can be used in research related to non-small cell lung cancer (NSCLC) .
    Akt/mTOR-IN-1
  • HY-162806
    PI3K/Akt/mTOR activator 1

    		Akt PI3K Autophagy Apoptosis mTOR Cardiovascular Disease
    PI3K/Akt/mTOR activator 1 (compound 11) is an anti-myocardial injury agent with cardioprotective activity. PI3K/Akt/mTOR activator 1 can significantly activate the PI3K/AKT/mTOR pathway and inhibit isoprenaline (HY-108353)-induced excessive autophagy and apoptosis in cardiomyocytes .
    PI3K/Akt/mTOR activator 1
  • HY-N0901B
    Corynoxine hydrochloride

    		Autophagy Neurological Disease Cancer
    Corynoxine hydrochloride, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria macrophylla. Corynoxine hydrochloride is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .
    Corynoxine hydrochloride
  • HY-151137
    HSP90/mTOR-IN-1

    		mTOR HSP Apoptosis Autophagy Cancer
    HSP90/mTOR-IN-1 is a potent and orally active Hsp90 and mTOR inhibitor with IC50 values of 69 nM and 29 nM, respectively. HSP90/mTOR-IN-1 suppresses the proliferation of SW780 cells through the over-activation of the PI3K/AKT/mTOR pathway. HSP90/mTOR-IN-1 induces apoptosis and autophagy via selective Hsp90 and mTOR inhibition. HSP90/mTOR-IN-1 also has considerable in vivo anti-tumor activity. HSP90/mTOR-IN-1 can be used for researching bladder cancer .
    HSP90/mTOR-IN-1
  • HY-D2227
    IR-58

    		Autophagy Apoptosis Cancer
    IR-58, a mitochondria-targeting near-infrared (NIR) fluorophore, is an autophagy enhancer. IR-58 kills tumour cells and induces apoptosis via inducing excessive autophagy, which is mediated through the reactive oxygen species (ROS)-Akt-mTOR pathway .
    IR-58

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