2. PI3K/Akt/mTOR Apoptosis Cell Cycle/DNA Damage
  3. Akt mTOR Caspase CDK
  4. Akt/mTOR-IN-1

Akt/mTOR-IN-1 (Compound 8r) is an AKT/mTOR signaling pathway inhibitor exhibiting an IC50 value of 0.8 µM with anticancer activity. Akt/mTOR-IN-1 can decrease the expression of Caspase 3 and increase the expression of the autophagic protein Cyclin B1, thereby inducing cell autophagy and apoptosis. Akt/mTOR-IN-1 can be used in research related to non-small cell lung cancer (NSCLC).

For research use only. We do not sell to patients.

Akt/mTOR-IN-1 Chemical Structure

Akt/mTOR-IN-1 Chemical Structure

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Akt/mTOR-IN-1 Related Antibodies

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mTOR mTORC1 mTORC2

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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Description

Akt/mTOR-IN-1 (Compound 8r) is an AKT/mTOR signaling pathway inhibitor exhibiting an IC50 value of 0.8 µM with anticancer activity. Akt/mTOR-IN-1 can decrease the expression of Caspase 3 and increase the expression of the autophagic protein Cyclin B1, thereby inducing cell autophagy and apoptosis. Akt/mTOR-IN-1 can be used in research related to non-small cell lung cancer (NSCLC)[1].

IC50 & Target

Caspase 3

 

In Vitro

Akt/mTOR-IN-1 (10 μM, 72 h) exhibits effective inhibitory activity in HepG2, MCF-7, and MDA-MB-231 cells[1].
Akt/mTOR-IN-1 (2 μM, 12 h) induces autophagy cell death and apoptosis via AKT/mTOR signaling pathway in non-small cell lung cancer (NSCLC) A549 cells[1].
Akt/mTOR-IN-1 (0.3125-10 μM, 24 h) induces G2/M cell cycle arrest and apoptosis in non-small cell lung cancer (NSCLC) A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Akt/mTOR-IN-1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF-7 cells, MDA-MB-231 cells, HepG2 cells
Concentration: 10 μM
Incubation Time: 72 h
Result: Inhibited the proliferation of cancer cell lines. The IC50 values for HepG2, MCF-7, and MDA-MB-231 cells were 1.3, 0.5, and 0.8, respectively.

Cell Cycle Analysis[1]

Cell Line: Non-small cell lung cancer (NSCLC) A549 cells
Concentration: 0.3125, 0.625, 1.25, 2.5, 5, 10 μM
Incubation Time: 24 h
Result: Led to G2/M cell cycle arrest.

Western Blot Analysis[1]

Cell Line: Non-small cell lung cancer (NSCLC) A549 cells
Concentration: 0.5, 1, 5, 10 μM
Incubation Time: 12 h
Result: Could increase LC3B-II protein level and decrease Lamp1 protein level in a dose-dependent manner.
Molecular Weight

526.51

Formula

C31H21F3N2O3
SMILES

O=C1NC(C2(O)C=CC(C=C2)=O)=C(C3=CC=C(C(F)(F)F)C=C3)C4=C1N(CC5=CC=CC=C5)C6=C4C=CC=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Akt/mTOR-IN-1 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Akt/mTOR-IN-1AktmTORCaspaseCDKPKBProtein kinase BMammalian target of RapamycinCyclin dependent kinaseMCF-7 cellsMDA-MB-231 cellsHepG2 cellsNon-small cell lung cancer (NSCLC) A549 cells Anticancer activityCancerInhibitorinhibitorinhibit

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