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CNI1493

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15509A
    Semapimod tetrahydrochloride
    2 Publications Verification

    CNI-1493; CPSI-2364 tetrahydrochloride

    		 TNF Receptor Interleukin Related p38 MAPK Inflammation/Immunology Cancer
    Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders .
    Semapimod tetrahydrochloride
  • HY-15509
    Semapimod

    CNI-1493 free base; CPSI-2364

    		 Interleukin Related TNF Receptor p38 MAPK Inflammation/Immunology Cancer
    Semapimod, an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod has potential in a variety of inflammatory and autoimmune disorders .
    Semapimod

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