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DCAF15

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Carbonic Anhydrase (1) Molecular Glues (2) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (3)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

dCeMM1	Molecular Glues	Cancer
dCeMM1 is a RBM39 glue degrader. dCeMM1 shows functions by re-directing the activity of the CRL4 ^DCAF15 ligase. dCeMM1 decreases the expression of RBM39 levels in WT KBM7 cells .

Indisulam 5+ Cited Publications E 7070	Molecular Glues Carbonic Anhydrase	Cancer
Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to *DCAF15* .

DCAF15 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DCAF15 Human Pre-designed siRNA Set A contains three designed siRNAs for DCAF15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DCAF15 Human Pre-designed siRNA Set A DCAF15 Human Pre-designed siRNA Set A

E3 ligase Ligand 24	Others	Cancer
E3 ligase Ligand 24 (Compound 24) is a Potent Ligand for the E3 Ligase DCAF15 (IC₅₀= 0.053 μM). Due to E3 ligase Ligand 24’s selectivity and potent binding characteristics, it is pivotal in the study of targeted protein degradation .

Cat. No.	Compare	Product Name	Species	Source

	DCAF15 Protein, Human (Sf9) DCAF15; DDB1- and CUL4-associated factor 15	Human	Sf9 insect cells
	DCAF15 serves as a substrate recognition component in the DCX (DCAF15) complex, coordinating the ubiquitination and degradation of target proteins and may affect NK cell function and APC-NK cell interactions. Notably, arylsulfonamide anticancer drugs alter the substrate specificity of the complex, promoting ubiquitination and degradation of RBM39, RBM23, and PRPF39. DCAF15 Protein, Human (Sf9) is the recombinant human-derived DCAF15 protein, expressed by Sf9 insect cells , with tag free. The total length of DCAF15 Protein, Human (Sf9) is 599 a.a., .

	DCAF15-DDB1 Protein, Human (Sf9, His, Strep) DCAF15-DDB1 complex; DCAF15; DDB1- and CUL4-associated factor 15	Human	Sf9 insect cells
	DCAF15 serves as a substrate recognition component in the DCX (DCAF15) complex, coordinating the ubiquitination and degradation of target proteins and may affect NK cell function and APC-NK cell interactions. Notably, arylsulfonamide anticancer drugs alter the substrate specificity of the complex, promoting ubiquitination and degradation of RBM39, RBM23, and PRPF39. DCAF15-DDB1 Protein, Human (Sf9, His, Strep) is the recombinant human-derived DCAF15-DDB1 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag.

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DCAF15 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
DCAF15 Human Pre-designed siRNA Set A contains three designed siRNAs for DCAF15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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