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Pathways Recommended: Antibody-drug Conjugate/ADC Related
Results for "

DLL4 Antibody

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

5

Inhibitory Antibodies

2

Natural
Products

Cat. No. Product Name Target Research Area
  • HY-P99261
    Demcizumab

    OMP 21M18; Human Anti-TNFRSF10B Recombinant Antibody

    		 Notch Cancer
    Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent inhibitor of the Notch pathway. Demcizumab alone or in combination with chemotherapy is effective in various cancer models .
  • HY-P99925
    Enoticumab

    REGN421

    		 Notch Metabolic Disease Cancer
    Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4. DLL4 is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively .
  • HY-P990252
    Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)

    		Inhibitory Antibodies Others
    Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) is a Armenian hamster-derived IgG, κ type antibody inhibitor, targeting to mouse Delta-like protein 4/DLL4.
  • HY-P99377
    Navicixizumab

    OMP-305B83; Anti-DLL4 Reference Antibody (navicixizumab)

    		 Notch Cancer
    Navicixizumab (OMP-305B83) is a bispecific anti-VEGF and anti-DLL4 inhibitory antibody. Navicixizumab can combine with Paclitaxel (HY-B0015) for cancer research. Navicixizumab can be used in the research of ovarian, primary peritoneal, or fallopian tube cancer .
  • HY-P990402
    Anti-DLL4 Antibody

    		Inhibitory Antibodies Inflammation/Immunology

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