FOXO1

Isoforms Recommended:	FOXO1

By Targets:	Akt (2) AMPK (1) Apoptosis (3) Autophagy (3) DYRK (1) FOXO (2) Glucosidase (1) HDAC (1) Histone Demethylase (1) PD-1/PD-L1 (1) PI3K (1) PPAR (1) Sirtuin (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Inflammation/Immunology (2) Metabolic Disease (8) Neurological Disease (4)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153617

FOXO1-IN-3	FOXO	Metabolic Disease
FOXO1-IN-3 is a highly-selective and orally active *FOXO1* inhibitor. FOXO1-IN-3 reduces hepatic glucose production in mice. FOXO1-IN-3 improves insulin sensitivity and glucose control in db/db mice without causing weight gain ^[1].

HY-100596

AS1842856 Maximum Cited Publications 51 Publications Verification	Autophagy	Metabolic Disease
AS1842856, a specific *Foxo1* inhibitor (IC₅₀=30 nM), potently suppresses autophagy ^[1]. AS1842856 only reduces the activity of FoxO1 by binding with it, without affecting its transcription and protein expression .

HY-153347

JY-2	FOXO	Metabolic Disease
JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC₅₀ of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity ^[1].

HY-123046

AS1708727 3 Publications Verification	Autophagy	Metabolic Disease Cancer
AS1708727 is an orally active *Foxo1* inhibitor, with EC₅₀ values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively ^[1].

HY-139348

PFI-90	Histone Demethylase Apoptosis	Cancer
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits *PAX3-FOXO1* action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).

HY-N7676

Marein 1 Publications Verification	AMPK HDAC	Cardiovascular Disease Neurological Disease Metabolic Disease
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects ^[1] .

HY-RS05069

FOXO1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FOXO1 Human Pre-designed siRNA Set A contains three designed siRNAs for FOXO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FOXO1 Human Pre-designed siRNA Set A FOXO1 Human Pre-designed siRNA Set A

HY-111299

Psammaplysene A	Apoptosis	Cancer
Psammaplysene A, a brominated tyrosine derivative, can promote the nuclear localization of *FOXO1, leading to cell cycle arrest and apoptosis*, and can be used in cancer research ^[1].

HY-N3542

Carpachromene	Glucosidase	Cancer
Carpachromene is a potent α-glucosidase enzyme inhibitor. Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway ^[1].

HY-122959

Kihadanin B	Akt PPAR	Metabolic Disease
Kihadanin B is a citrus limonoid that can be purified from the peels of immature Citrus unshiu. Kihadanin B suppresses adipogenesis through repression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes ^[1].

HY-P4790

Acetyl-Exenatide	PI3K Akt	Metabolic Disease
Acetyl-Exenatideyes is an acetylated derivative of Exenatide. Exenatide has the function similar to insulin, which can be used for research of type 2 diabetes. Exenatide can promote Th17 differentiation, inhibits Tregs differentiation, downregulates PI3K/Akt/FoxO1 phosphorylation ^[1].

HY-15145A

SRT 1720 dihydrochloride 35+ Cited Publications	Sirtuin Autophagy	Metabolic Disease
SRT 1720 dihydrochloride is a selective and orally active activator of *SIRT1* with an EC₅₀ of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 ^[1].

HY-149216

Anticancer agent 103	Others	Cancer
Anticancer agent 103 (Compound 2k) is a potent anticancer agent ^[1].

HY-P99422

Adebrelimab SHR-1316	PD-1/PD-L1 Apoptosis	Cancer
Adebrelimab (SHR-1316) is a humanized IgG4 monoclonal *PD-L1* (PD-1/PD-L1) antibody. Adebrelimab has promising antitumor activity in solid tumors including extensive-stage small-cell lung cancer (SCLC) ^[1] .

HY-N0748

Oxypaeoniflorin 3 Publications Verification	Others	Neurological Disease Inflammation/Immunology
Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects ^[1] .

HY-N0748R

Oxypaeoniflorin (Standard)	Others	Neurological Disease Inflammation/Immunology
Oxypaeoniflorin (Standard) is the analytical standard of Oxypaeoniflorin. This product is intended for research and analytical applications. Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects ^[1] .

HY-111380

EHT 1610 1 Publications Verification	DYRK	Neurological Disease
EHT 1610 is a potent inhibitor of DYRK, with IC₅₀s of 0.36 nM (DYRK1A), 0.59 nM (DYRK1B), respectively. EHT 1610 exhibits antileukemia effect, regulates cell cycle and induces cell apoptosis ^[1] ^- .

Cat. No.	Product Name	Target	Research Area

HY-P4790

Acetyl-Exenatide	PI3K Akt	Metabolic Disease
Acetyl-Exenatideyes is an acetylated derivative of Exenatide. Exenatide has the function similar to insulin, which can be used for research of type 2 diabetes. Exenatide can promote Th17 differentiation, inhibits Tregs differentiation, downregulates PI3K/Akt/FoxO1 phosphorylation ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P99422

Adebrelimab SHR-1316	PD-1/PD-L1 Apoptosis	Cancer
Adebrelimab (SHR-1316) is a humanized IgG4 monoclonal *PD-L1* (PD-1/PD-L1) antibody. Adebrelimab has promising antitumor activity in solid tumors including extensive-stage small-cell lung cancer (SCLC) ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7676

Marein 1 Publications Verification	Cardiovascular Disease Flavonoids Chalcones other families Classification of Application Fields Neurological Disease Source classification Phenols Polyphenols Plants Disease Research Fields	AMPK HDAC
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects ^[1] .

HY-P99422

Adebrelimab SHR-1316	Classification of Application Fields Disease Research Fields Cancer	PD-1/PD-L1 Apoptosis
Adebrelimab (SHR-1316) is a humanized IgG4 monoclonal *PD-L1* (PD-1/PD-L1) antibody. Adebrelimab has promising antitumor activity in solid tumors including extensive-stage small-cell lung cancer (SCLC) ^[1] .

HY-N0748

Oxypaeoniflorin 3 Publications Verification	Structural Classification Other Monoterpenes Monophenols Paeonia lactiflora Pall. Terpenoids Source classification Phenols Plants Paeoniaceae	Others
Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects ^[1] .

HY-N3542

Carpachromene	Structural Classification Flavonoids Flavones Source classification Plants Calophyllaceae Calophyllum symingtonianum M.R.Hend. & Wyatt-Sm.	Glucosidase
Carpachromene is a potent α-glucosidase enzyme inhibitor. Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway ^[1].

HY-122959

Kihadanin B	Other Terpenoids Structural Classification Terpenoids Dictamnus dasycarpus Turcz. Source classification Rutaceae Plants	Akt PPAR
Kihadanin B is a citrus limonoid that can be purified from the peels of immature Citrus unshiu. Kihadanin B suppresses adipogenesis through repression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes ^[1].

HY-N0748R

Oxypaeoniflorin (Standard)	Structural Classification Other Monoterpenes Monophenols Paeonia lactiflora Pall. Terpenoids Source classification Phenols Plants Paeoniaceae	Others
Oxypaeoniflorin (Standard) is the analytical standard of Oxypaeoniflorin. This product is intended for research and analytical applications. Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects ^[1] .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81074

	FOXO1 Antibody FOXO1; FKHR; FOXO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma	WB, IHC-F, IHC-P, ICC/IF, ELISA, ChIP	Human, Mouse, Rat, Pig
	FOXO1 Antibody is a rabbit-derived non-conjugated IgG antibody, targeting FOXO1, with a predicted molecular weight of 78 kDa . FOXO1 Antibody can be used for WB, IHC-F, IHC-P, ICC/IF, ELISA, ChIP experiments in human, mouse, rat, pig backgrounds.

HY-P80676

	FOXO1 Antibody (YA430) FOXO1; FKHR; FOXO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma	WB, IHC-F, IHC-P, ICC/IF	Human
	FOXO1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 70 kDa, targeting to FOXO1. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human.

HY-P80132

	FOXO1A Antibody	WB, ICC/IF, IHC-P	Human, Mouse
	FOXO1A Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 70 kDa, targeting to FOXO1A. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human, Mouse.

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Cat. No.	Product Name		Classification

HY-RS05069

FOXO1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
FOXO1 Human Pre-designed siRNA Set A contains three designed siRNAs for FOXO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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