Psammaplysene A

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Psammaplysene A, a brominated tyrosine derivative, can promote the nuclear localization of FOXO1, leading to cell cycle arrest and apoptosis, and can be used in cancer research.

For research use only. We do not sell to patients.

Psammaplysene A Chemical Structure

CAS No. : 850013-02-4

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Description

Psammaplysene A, a brominated tyrosine derivative, can promote the nuclear localization of FOXO1, leading to cell cycle arrest and apoptosis, and can be used in cancer research^[1].

In Vitro

Psammaplysene A (1-1000 nM, 24 h) can induce apoptosis of endometrial cancer cells Ishikawa and ECC1, and affect cell viability and cycle distribution^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Ishikawa and ECC1 cells
Concentration:	1 nM, 10 nM, 100 nM and 1 μM
Incubation Time:	24 h
Result:	Increased nuclear FOXO1 protein levels in both cell lines at a concentration of 1 μM. Did not significantly affect cell viability at a concentration of 100 nM, but significantly reduced the number of viable cells by approximately 5-fold at 1 μM.

Cell Cycle Analysis^[1]

Cell Line:	Ishikawa and ECC1 cells
Concentration:	100 nM, 500 nM, and 1 μM
Incubation Time:	24 h
Result:	Significantly increased the percentage of cells in G2/M phase in both cell lines at 1 μM.

Molecular Weight

769.20

Formula

C₂₇H₃₅Br₄N₃O₃

CAS No.

850013-02-4

SMILES

O=C(NCCCOC1=C(Br)C=C(CCN(C)C)C=C1Br)/C=C/C2=CC(Br)=C(OCCCN(C)C)C(Br)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Emily Berry, et al. Induction of apoptosis in endometrial cancer cells by psammaplysene A involves FOXO1. Gynecol Oncol. 2009 Feb;112(2):331-6.

Psammaplysene A Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Psammaplysene A850013-02-4ApoptosisFOXO1cell cycleapoptosiscancerInhibitorinhibitorinhibit

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