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Glycyrrhiza uralensis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Aldose Reductase (3) Amyloid-β (2) Apoptosis (5) Autophagy (3) Bacterial (5) Beta-secretase (1) CCR (1) COX (2) Cytochrome P450 (1) Endogenous Metabolite (3) Estrogen Receptor/ERR (1) Glucosidase (1) HIV (1) Influenza Virus (2) MMP (1) NF-κB (3) NOD-like Receptor (NLR) (1) p38 MAPK (1) Parasite (1) Phosphatase (1) PPAR (1) Reactive Oxygen Species (3)
By Research Areas:	Cancer (13) Cardiovascular Disease (1) Endocrinology (1) Infection (7) Inflammation/Immunology (15) Metabolic Disease (6) Neurological Disease (6)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N9919

Glyasperin C	Others	Others
Glyasperin C is a potent and reversible noncompetitive inhibitor of neuraminidase with an IC₅₀ of 20% at 200 μM. Glyasperin C is a polyphenol isolated from the roots of Glycyrrhiza uralensis .

HY-N2122

Neoisoliquiritin Neoisoliquiritigenin	Others	Cancer
Neoisoliquiritin is a bioactive component isolated from Glycyrrhiza uralensis .

HY-N2123

Neoliquiritin	Others	Inflammation/Immunology
Neoliquiritin is isolated from Glycyrrhiza uralensis with an anti-inflammatory activity .

HY-N6981

Methyl Glycyrrhizate	Others	Metabolic Disease Cancer
Methyl Glycyrrhizate, derived from Glycyrrhiza uralensis Fisch., is the ester of methyl alcohol and Glycyrrhizic Acid .

HY-N8609

Uralsaponin C	Others	Others
Uralsaponin C is an analogue of oleanane-type triterpenoid saponin. Uralsaponin C can be isolated from the roots of Glycyrrhiza uralensis Fisch .

HY-N3920

Gancaonin G	Bacterial	Infection
Gancaonin G is a 6-prenylated isoflavanone that can be isolated from Glycyrrhiza uralensis. Gancaonin G has antibacterial activity against Streptococcus mutants and MRSA strains .

HY-142096

Glycyuralin E	Others	Others
Glycyuralin E is a natural product that can be isolated from Glycyrrhiza uralensis .

HY-N3922

Gancaonin M	Others	Others
Gancaonin M is a Flavonoids product that can be isolated from the roots of Glycyrrhiza uralensis Fisch .

HY-N6975

Glyasperin D	Bacterial	Infection
Glyasperin D is a flavonoid isolated from Glycyrrhiza uralensis, and possesses weaker anti-Helicobacter pylori activity .

HY-N3385

Licorisoflavan A 7-O-Methyllicorisoflavan B	Others	Others
Licorisoflavan A (7-O-Methyllicorisoflavan B) is a isoflavan-quinone, that can be isolated from Glycyrrhiza uralensis .

HY-N0180

18β-Glycyrrhetinic acid 5+ Cited Publications	Endogenous Metabolite	Inflammation/Immunology Cancer
18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

HY-N4186

Glabrolide	Beta-secretase	Neurological Disease
Glabrolide, derived from Glycyrrhiza uralensis Fisch., is a β-secretase 1 (BACE-1) inhibitor[1].

HY-N6583

Licoflavonol	Bacterial	Infection
Licoflavonol, a minor flavone from the roots of Glycyrrhiza uralensis, is an inhibitor of the Salmonella type III secretion system (T3SS) .

HY-N6911

Licorice-saponin H2 (18β,20α)-Glycyrrhizic acid	Others	Metabolic Disease
Licorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) is a saponin from Glycyrrhiza uralensis Fischer .

HY-W049311

4-Methyl-5,6,7,8-tetrahydroquinoline	Others	Others
4-Methyl-5,6,7,8-tetrahydroquinoline, a tetrahydroquinoline alkaloid, is isolated from the roots of Glycyrrhiza uralensis Fisch .

HY-N2123R

Neoliquiritin (Standard)	Others	Inflammation/Immunology
Neoliquiritin (Standard) is the analytical standard of Neoliquiritin. This product is intended for research and analytical applications. Neoliquiritin is isolated from Glycyrrhiza uralensis with an anti-inflammatory activity .

HY-N0377

Liquiritigenin 5 Publications Verification 4',7-Dihydroxyflavanone	Estrogen Receptor/ERR	Neurological Disease Inflammation/Immunology Cancer
Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC₅₀ of 36.5 nM for activation of the ERE tk-Luc.

HY-N4182

Licochalcone E	Akt p38 MAPK Autophagy	Inflammation/Immunology
Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation .

HY-N6989

Isoglycycoumarin	Cytochrome P450	Metabolic Disease
Isoglycycoumarin is a flavonoid isolated from the roots of Glycyrrhiza uralensis. Isoglycycoumarin is a highly selective probe for human cytochrome P450 2A6 (CYP2A6) .

HY-N11771

Glyurallin B	Others	Others
Glyurallin B is a flavonoid, that can be isolated from licorice (Glycyrrhiza inflata and Glycyrrhiza uralensis). Glyurallin B shows ABTS ⁺ radical scavenging activity and the inhibitory activity on lipid peroxidation, with EC₅₀ values of 11.9 ± 0.58 μM and 15.3 ± 1.26 μM, respectivley .

HY-N8947

Glyurallin A	Endogenous Metabolite Glucosidase	Metabolic Disease
Glyurallin A (Compound 79) is isolated from the naturalGlycyrrhiza uralensis. Glyurallin A inhibitsα-Glucosidase(HY-P2802)(IC₅₀=0.3 μM). Glyurallin A can be used in the study of anti-diabetes .

HY-N4185

Licoflavone A 1 Publications Verification	Phosphatase	Neurological Disease
Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B), with an IC₅₀ of 54.5 μM .

HY-N0102

Isoliquiritigenin Maximum Cited Publications 18 Publications Verification GU17; ISL; Isoliquiritigen; SJ000286237	Aldose Reductase Influenza Virus Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC₅₀ of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC₅₀ of 24.7 μM.

HY-N3961

Neoglycyrol	Others	Cardiovascular Disease
Neoglycyrol is isolated from the root of Glycyrrhiza uralensis Fisch . Neoglycyrol is a potential myocardial protection active compound screened from traditional patent medicine Tongmai Yangxin pill (TMYXP) .

HY-121054

Chalcone	Bacterial Parasite	Inflammation/Immunology Cancer
Chalcone is isolated from Glycyrrhiza uralensis and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities .

HY-N4187

Licochalcone D 3 Publications Verification	NF-κB Apoptosis Reactive Oxygen Species	Metabolic Disease Inflammation/Immunology Cancer
Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65. Licochalcone D possesses antioxidant, anti-inflammatory, anti-cancer properties .

HY-N0180R

18β-Glycyrrhetinic acid (Standard)	Endogenous Metabolite	Inflammation/Immunology Cancer
18β-Glycyrrhetinic acid (Standard) is the analytical standard of 18β-Glycyrrhetinic acid. This product is intended for research and analytical applications. 18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

HY-N6980

Licorice glycoside C2 1 Publications Verification	HIV	Infection Cancer
Licorice glycoside C2 is a oleanane-type triterpene oligoglycoside isolated from Glycyrrhiza uralensis. Various biological activities are associated with licorice extracts, such as anti-viral, anti-microbial, antioxidant, anti-inflammatory, anti-ulcer, anti-cancer and anti-HIV effects .

HY-N0102R

Isoliquiritigenin (Standard)	Aldose Reductase Influenza Virus Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Isoliquiritigenin (Standard) is the analytical standard of Isoliquiritigenin. This product is intended for research and analytical applications. Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.

HY-N1280

Semilicoisoflavone B	Amyloid-β	Neurological Disease
Semilicoisoflavone B, an isoflavone, mainly derived from Glycyrrhiza uralensis Fisch.. Semilicoisoflavone B reduces amyloid β (Aβ) secretion by inhibiting β-secretase-1 (BACE1) expression and activity. Semilicoisoflavone B decreases BACE1 expression mainly through increasing PPARγ expression and inhibiting STAT3 phosphorylation .

HY-N0393R

Glabridin (Standard)	PPAR Reactive Oxygen Species Bacterial	Infection Inflammation/Immunology Cancer
Glabridin (Standard) is the analytical standard of Glabridin. This product is intended for research and analytical applications. Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC₅₀ of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities .

HY-N3716

Dehydroglyasperin D	Aldose Reductase COX	Metabolic Disease Inflammation/Immunology
Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC₅₀: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi .

HY-N0376

Liquiritin 5+ Cited Publications	Reactive Oxygen Species	Neurological Disease Inflammation/Immunology Cancer
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC₅₀s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

HY-N0373

Licochalcone B 5 Publications Verification	Amyloid-β Apoptosis NOD-like Receptor (NLR)	Neurological Disease
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (₄₂) self-aggregation (IC₅₀=2.16 μM) and disaggregate pre-formed Aβ₄₂ fibrils, reduce metal-induced Aβ₄₂ aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction .

HY-N3387

Licoricidin	Apoptosis NF-κB Akt MMP	Inflammation/Immunology Cancer
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC₅₀=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer . Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect . Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo . Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations .

HY-N2609

7,4'-Dihydroxyflavone 1 Publications Verification	COX CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

Glyasperin C	Flavonoids Classification of Application Fields Leguminosae Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones	Others
Glyasperin C is a potent and reversible noncompetitive inhibitor of neuraminidase with an IC₅₀ of 20% at 200 μM. Glyasperin C is a polyphenol isolated from the roots of Glycyrrhiza uralensis .

Neoisoliquiritin Neoisoliquiritigenin	Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Others
Neoisoliquiritin is a bioactive component isolated from Glycyrrhiza uralensis .

Neoliquiritin	Flavonoids Monophenols Classification of Application Fields Leguminosae Flavonones Source classification Phenols Plants Disease Research Fields Inflammation/Immunology Glycyrrhiza uralensis Fisch.	Others
Neoliquiritin is isolated from Glycyrrhiza uralensis with an anti-inflammatory activity .

18β-Glycyrrhetinic acid 5+ Cited Publications	Triterpenes Structural Classification Classification of Application Fields Leguminosae Terpenoids Source classification Plants Endogenous metabolite Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

Uralsaponin C	Triterpenes Structural Classification Leguminosae Ketones, Aldehydes, Acids Terpenoids Source classification Plants Glycyrrhiza uralensis Fisch.	Others
Uralsaponin C is an analogue of oleanane-type triterpenoid saponin. Uralsaponin C can be isolated from the roots of Glycyrrhiza uralensis Fisch .

Gancaonin G	Structural Classification Flavonoids Flavones Leguminosae Source classification Plants Glycyrrhiza uralensis Fisch.	Bacterial
Gancaonin G is a 6-prenylated isoflavanone that can be isolated from Glycyrrhiza uralensis. Gancaonin G has antibacterial activity against Streptococcus mutants and MRSA strains .

Glycyuralin E	Structural Classification Natural Products Leguminosae Source classification Plants Glycyrrhiza uralensis Fisch.	Others
Glycyuralin E is a natural product that can be isolated from Glycyrrhiza uralensis .

Gancaonin M	Structural Classification Flavonoids Leguminosae Source classification Plants Glycyrrhiza uralensis Fisch. Isoflavones	Others
Gancaonin M is a Flavonoids product that can be isolated from the roots of Glycyrrhiza uralensis Fisch .

Glyasperin D	Infection Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch.	Bacterial
Glyasperin D is a flavonoid isolated from Glycyrrhiza uralensis, and possesses weaker anti-Helicobacter pylori activity .

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Inhibitors & Agonists

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