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Results for "

ISR

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Biochemical Assay Reagents

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153074
    ISR-IN-1

    		Others Cancer
    ISR-IN-1 (Compound 48) is an inhibitor of the integrated stress response (EC50: 0.6 nM) .
    ISR-IN-1
  • HY-153075
    ISR-IN-2

    		Others Cancer
    ISR-IN-2 (Compound 47) is an inhibitor of the integrated stress response (EC50: 0.8 nM) .
    ISR-IN-2
  • HY-12495A
    ISRIB
    10+ Cited Publications

    		 Biochemical Assay Reagents Eukaryotic Initiation Factor (eIF) Neurological Disease
    ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research .
    ISRIB
  • HY-153339
    E235

    		Others Cancer
    E235 is an expression regulator of activates transcription factor 4 (ATF4). E235 reduces cell viability by activating integrated stress response (ISR) and DNA damage response signals. E235 has anti-proliferative activity and can be used for tumor research .
    E235
  • HY-149555
    DNL343

    		Eukaryotic Initiation Factor (eIF) Neurological Disease
    DNL343 is a potent, selective, orally active and brain-penetrant activator of eukaryotic initiation factor eIF2B. DNL343 inhibits the activity of the integrated stress response (ISR) in the central nervous system (CNS) and reverses neurodegeneration and neuroinflammation. DNL343 also prevents motor dysfunction and premature death in eIF2B loss-of-function (LOF) mutant mice. DNL343 can be used in the study of neurodegenerative diseases .
    DNL343
  • HY-164026
    ISR modulator-1

    		Others Cancer
    ISR modulator-1 (Compound 212) is a modulator for integrated stress response pathway (ISR)
    ISR modulator-1
  • HY-162863
    ERK-MYD88 interaction inhibitor 1

    		Apoptosis Cancer
    ERK-MYD88 interaction inhibitor 1 is an ERK-MYD88 interaction inhibitor. ERK-MYD88 interaction inhibitor 1 can induce an HRI-mediated integrated stress response (ISR), leading to cancer cell-specific immunogenic cell apoptosis (apoptosis). ERK-MYD88 interaction inhibitor 1 can induce anti-tumor T cell responses in Lewis lung cancer mice, exhibiting anti-tumor activity .
    ERK-MYD88 interaction inhibitor 1
  • HY-153399
    Fosigotifator

    		Others Cancer
    Fosigotifator is modulates the integrated stress response (ISR) for inhibition of ISR-related diseases .
    Fosigotifator
  • HY-153399A
    ABBV-CLS-7262

    Fosigotifator THAM sodium

    		 Others Cancer
    ABBV-CLS-7262 is modulates the integrated stress response (ISR) for inhibition of ISR-related diseases .
    ABBV-CLS-7262
  • HY-158198
    PRXS571

    		Others Neurological Disease
    PRXS571 is a potent modulator of the neuronal integrated stress response (ISR) and can be used in neural-related research .
    PRXS571

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